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Submit ReviewME 0328
说明： Selective PARP-3 inhibitor
化学名： 3,4-Dihydro-4-oxo-3,4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide
纯度： ≥98% (HPLC)
生物活性 for ME 0328
ME 0328 is an inhibitor of PARP-3 (IC50 = 0.89 μM). Displays selectivity for PARP-3 over PARP-1, PARP-2 and other ARDT enzymes (IC50 values are 6.3, 10.8 and >30 μM respectively). Enhances CRISPR-Cas9-mediated HER2 mutation frequency, resulting in increased reduction in proliferation of HER2-positive breast cancer cells. Cell permeable.
技术数据 for ME 0328
| 分子量 | 321.37 |
| 公式 | C19H19N3O2 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1445251-22-8 |
| PubChem ID | 71571526 |
| InChI Key | QIHBWVVVRYYYRO-ZDUSSCGKSA-N |
| Smiles | O=C2NC(CCC(N[C@@H](C)C3=CC=CC=C3)=O)=NC1=CC=CC=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for ME 0328
参考文献 for ME 0328
参考文献是支持产品生物活性的出版物。
Lindgren et al (2013) PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3. ACS Chem.Biol. 8 1698 PMID: 23742272
Wang and Sun (2016) CRISPR-mediated targeting of HER2 inhibits cell proliferation through a dominant negative mutation. Cancer Lett. PMID: 27815036
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关键词: ME 0328, ME 0328 supplier, ME0328, PARP3, ARDT3, inhibitors, inhibits, selective, CRISPR-Cas9, HER2, Poly(ADP-ribose), Polymerase, CRISPR, Reagents, 5054, Tocris Bioscience
1 篇 ME 0328 的引用文献
引用文献是使用了 Tocris 产品的出版物。 ME 0328 的部分引用包括：
Wang and Sun (2016) CRISPR-mediated targeting of HER2 inhibits cell proliferation through a dominant negative mutation. Cancer Letters 385 137 PMID: 27815036
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Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.