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Submit ReviewMEDICA 16
说明： FFA1 (GPR40) agonist; also inhibits ATP citrate lyase
化学名： 3,3,14,14-Tetramethylhexadecanedioic acid
生物活性 for MEDICA 16
MEDICA 16 is a free fatty acid 1 (FFA1/GPR40) receptor agonist; exhibits selectivity for FFA1 (GPR40) over GPR120. Also inhibits ATP citrate lyase; reduces intracellular triacylglycerol levels in muscle, inhibits lipogenesis and increases insulin sensitivity in rodents in vivo.
技术数据 for MEDICA 16
| 分子量 | 342.51 |
| 公式 | C20H38O4 |
| 储存 | Store at -20°C |
| CAS Number | 87272-20-6 |
| PubChem ID | 121871 |
| InChI Key | HYSMCRNFENOHJH-UHFFFAOYSA-N |
| Smiles | CC(CC(O)=O)(C)CCCCCCCCCCC(C)(C)CC(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for MEDICA 16
参考文献 for MEDICA 16
参考文献是支持产品生物活性的出版物。
Hara et al (2009) Novel selective ligands for free fatty acid receptors GPR120 and GPR40. Naunyn Schmiedebergs Arch.Pharmacol. 380 247 PMID: 19471906
Atkinson et al (2002) MEDICA 16 inhibits hepatic acetyl-CoA carboxylase and reduces plasma triacylglycerol levels in Ins-resistant JCR:LA-cp rats. Diabetes 51 1548 PMID: 11978655
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关键词: MEDICA 16, MEDICA 16 supplier, MEDICA16, free, fatty, acid, receptors, 1, FFA1, FFAR1, GPR40, agonists, ATP, citrate, lyases, inhibitors, inhibits, lipogenesis, insulin, sensitivity, triacylglyerol, synthases, transferases, ACLY, Free, Fatty, Acid, Receptors, Citrate, Lyase, 4615, Tocris Bioscience
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