Mefloquine hydrochloride

Cat. No. 6819 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Cx36 and Cx50 gap channel blocker; also antimalarial and antischistosomal

化学名： (αS)-rel-α-(2R)-2-Piperidinyl-2,3-bis(trifluoromethyl-4-quinolinemethanol hydrochloride

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Mefloquine hydrochloride

Mefloquine hydrochloride is a Cx36 and Cx50 gap channel blocker (IC₅₀ values are 0.3 and 1.1 μM, resepctively). Blocks gap junctional-coupling between interneurons in neocortical slices. Also antimalarial. Bind 80S ribosome of Plasmodium falciparum to inhibit protein synthesis. Improves survival in P berghei-infected mice. Additionally exhibits antischistosomal activity in vitro and in vivo. Exhibits antiviral activities against SARS-CoV-2 (IC₅₀ < 10 μM).

化合物库 for Mefloquine hydrochloride

Mefloquine hydrochloride is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Mefloquine hydrochloride

分子量	414.77
公式	C₁₇H₁₆F₆N_2O.HCl
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	51773-92-3
PubChem ID	65329
InChI Key	WESWYMRNZNDGBX-YLCXCWDSSA-N
Smiles	[H][C@]1([C@H](C2=CC(C(F)(F)F)=NC3=C(C(F)(F)F)C=CC=C23)O)CCCCN1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Mefloquine hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	ethanol	41.48	100
	DMSO	20.74	50

制备储备液 for Mefloquine hydrochloride

以下数据基于产品分子量 414.77。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.41 mL	12.05 mL	24.11 mL
5 mM	0.48 mL	2.41 mL	4.82 mL
10 mM	0.24 mL	1.21 mL	2.41 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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产品说明书 for Mefloquine hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Mefloquine hydrochloride

参考文献是支持产品生物活性的出版物。

Pasche et al (2019) Early antischistosomal leads identified from in vitro and in vivo screening of the Medicines for Malaria Venture Pathogen Box. ACS Infect.Dis. 5 102 PMID: 30398059

Wong et al (2017) Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis. Nat.Microbiol. 2 17031 PMID: 28288098

Cruikshank et al (2004) Potent block of Cx36 and Cx50 gap junction channels by meflo. Proc.Natl.Acad.Sci.U.S.A. 101 12364 PMID: 15297615

Ohnmacht et al (1971) Antimalarials. 7. Bis(trifluoromethyl)-α-(2-piperidyl)-4-quinolinemethanols. J.Med.Chem. 14 926 PMID: 5115690

Jeon et al (2020) Identification of antiviral drug candidates against SARS-CoV-2 from FDA-approved drugs. Antimicrob.Agents Chemother. 64 PMID: 32366720

If you know of a relevant reference for Mefloquine hydrochloride, please let us know.

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