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Submit ReviewMelanocyte-stimulating hormone release inhibiting factor is a inhibitor of melanocyte-stimulating hormone (MSH) release. Blocks the release of α-MSH, increases brain dopamine levels and antagonizes physiological and behavioral opioid effects in vivo.
分子量 | 284.36 |
公式 | C13H24N4O3 |
序列 |
PLG (Modifications: Gly-3 = C-terminal amide) |
储存 | Desiccate at -20°C |
CAS Number | 2002-44-0 |
PubChem ID | 92910 |
InChI Key | NOOJLZTTWSNHOX-UWVGGRQHSA-N |
Smiles | [H]N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
参考文献是支持产品生物活性的出版物。
Kavaliers and Hirst (1986) Inhibitory influences of FMRFamide and PLG on stress-induced opioid analgesia and activity. Brain Res. 372 370 PMID: 2871903
Mishra et al (1983) Pharmacology of L-Prolyl-L-Leucyl-Glycinamide (PLG): a review. Methods Find.Exp.Clin.Pharmacol. 5 203 PMID: 6136640
Plotnikoff and Kastin (1974) Pharmacological studies with a tripeptide, Prolyl-Leucyl Glycine amide. Arch.Int.Pharmacodyn.Ther. 211 211 PMID: 4156639
Pugsley and Lippmann (1977) Synthetic melanocyte stimulating hormone release inhibiting factor (MIF). Part III: effect of L-prolyl-N-MthD.-leucyl-glycinamide and MIF on biogenic amine turnover. Arzneimittelforschung 27 2293 PMID: 23796
关键词: Melanocyte-stimulating hormone release inhibiting factor, Melanocyte-stimulating hormone release inhibiting factor supplier, α-MSH, alpha-MSH, a-MSH, release, inhibits, inhibitors, melanocortin, receptors, Pro-Leu-Gly, amide, MIF-I, PLG, Miscellaneous/Non-selective, Opioids, Dopaminergic-Related, Melanocortin, Receptors, 1929, Tocris Bioscience
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Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.