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Submit ReviewMelanotan II
说明： High affinity melanocortin receptor agonist
别名： MT-II
纯度： ≥95% (HPLC)
生物活性 for Melanotan II
Melanotan II is a high affinity melanocortin receptor agonist (Ki values are 0.67, 6.6, 34 and 46 nM for MC1, MC4, MC3 and MC5 receptors respectively). Stimulates erectile activity, inhibits food intake and displays neuroprotective properties in vivo.
技术数据 for Melanotan II
| 分子量 | 1024.19 |
| 公式 | C50H69N15O9 |
| 序列 |
XDHFRWK (Modifications: X = Nle & N-terminal Ac, Asp-2 = β-Asp, Phe-4 = D-Phe, Lys-7 = ε-Lys, Cyclized = Asp-2 - Lys-7, C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 121062-08-6 |
| PubChem ID | 92432 |
| InChI Key | JDKLPDJLXHXHNV-MFVUMRCOSA-N |
| Smiles | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CNC=N2)NC1=O)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Melanotan II
| 溶解性 | Soluble to 0.70 mg/ml in water |
产品说明书 for Melanotan II
参考文献 for Melanotan II
参考文献是支持产品生物活性的出版物。
Martin et al (2002) Activation of melanocortin MC4 receptors increases erectile activity in rats ex copula. Eur.J.Pharmacol. 454 71 PMID: 12409007
Ter Laak et al (2003) The potent melanocortin receptor agonist melanotan-II promotes peripheral nerve regeneration and has neuroprotective properties in the rat. Eur.J.Pharmacol. 462 179 PMID: 12591111
Wikberg (1999) Melanocortin receptors: perspectives for novel drugs. Eur.J.Pharmacol. 375 295 PMID: 10443584
If you know of a relevant reference for Melanotan II, please let us know.
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关键词: Melanotan II, Melanotan II supplier, High, affinity, melanocortin, receptor, agonists, MC, Receptors, MelanotanII, MT-II, Melanocortin, 2566, Tocris Bioscience
1 篇 Melanotan II 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Melanotan II 的部分引用包括：
Nøhr et al (2017) The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW. Neurochem Int 102 105 PMID: 27916541
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该领域的文献
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.