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说明： Inhibits Gs and stimulates Gi activity
纯度： ≥95% (HPLC)
生物活性 for Melittin
Melittin is a inhibits Gs and stimulates Gi activity. Inhibits protein kinase C and cAMP-dependent protein kinases. Na+/K+ ATPase inhibitor.
技术数据 for Melittin
| 分子量 | 2847 |
| 公式 | C131H229N39O31 |
| 序列 |
GIGAVLKVLTTGLPALISWIKRKRQQ (Modification: Gln-26 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 20449-79-0 |
| PubChem ID | 16133648 |
| InChI Key | VDXZNPDIRNWWCW-JFTDCZMZSA-N |
| Smiles | [H]NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Melittin
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for Melittin
参考文献 for Melittin
参考文献是支持产品生物活性的出版物。
Fukushima et al (1998) Melittin, a metabostatic peptide inhibiting Gs activity. Peptides 5 811 PMID: 9663445
Mousli et al (1990) G protein activation: a receptor-independent mode of action for cationic amphiphilic neuropeptides and venom peptides. TiPS 11 358 PMID: 2122563
Raynor et al (1991) Membrane interactions of amphiphilic polypeptides mastoparan, melittin, plymixin B and cardiotoxin. J.Biol.Chem. 266 2753 PMID: 1847132
If you know of a relevant reference for Melittin, please let us know.
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关键词: Melittin, Melittin supplier, Inhibitors, inhibits, Gs, stimulates, stimulators, Gi, activity, protein, kinases, C, cAMP-dependent, G, Proteins, Heterotrimeric, PKC, G-protein, GTPases, Protein, Kinase, 1193, Tocris Bioscience
1 篇 Melittin 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Melittin 的部分引用包括：
Meitzen et al (2011) β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem 116 984 PMID: 21143600
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