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Submit ReviewMelperone hydrochloride
说明： 5-HT2A antagonist; also D2 antagonist; neuroleptic
化学名： 1-(4-Fluorophenyl)-4-(4-methyl-1-piperidinyl)-1-butanone hydrochloride
纯度： ≥99% (HPLC)
生物活性 for Melperone hydrochloride
Melperone hydrochloride is an atypical neuroleptic; 5-HT2A/D2 receptor antagonist (Ki values are 120 and 180 nM respectively). Causes an increase in dopamine levels in the medial prefrontal cortex (mPFC) and nucleus accumbens and an increase in ACh in the mPFC. Also binds adrenergic α1 and α2 receptors (Ki values are 180 and 150 nM respectively).
技术数据 for Melperone hydrochloride
| 分子量 | 299.81 |
| 公式 | C16H22FNO.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 1622-79-3 |
| PubChem ID | 15386 |
| InChI Key | MQHYXXIJLKFQGY-UHFFFAOYSA-N |
| Smiles | Cl.CC1CCN(CCCC(=O)C2=CC=C(F)C=C2)CC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Melperone hydrochloride
参考文献 for Melperone hydrochloride
参考文献是支持产品生物活性的出版物。
Seeman et al (1997) Atypical neuroleptics have low affinity for DA D2 receptors or are selective for D4 receptors. Neuropsychopharmacology. 16 93 PMID: 9015795
Ichikawa et al (2002) Atypical antipsychotic drugs, quetiapine, iloperidone, and melperone, preferentially increase DA and acetylcholine release in rat medial prefrontal cortex: role of 5-HT1A receptor agonism. Brain Res. 956 349 PMID: 12445705
Uhr et al (2005) P-glycoprotein is a factor in the uptake of dextromethorphan, but not of melperone, into mouse brain: evidence for an overlap in substrate specificity between P-gp and CYP2D6. J.Psychopharmacol. 18 509
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关键词: Melperone hydrochloride, Melperone hydrochloride supplier, 5-HT2A/D2, receptor, antagonists, neuroleptic, Serotonin, Receptors, Dopamine, D2, dopaminergic, 5-HT2A, 2495, Tocris Bioscience
1 篇 Melperone hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Melperone hydrochloride 的部分引用包括：
Hacker et al (2015) Substrate-Dependent Inhibition of the Human Organic Cation Transporter OCT2: A Comparison of MetF. with Experimental Substrates. Brain Res 10 e0136451 PMID: 26327616
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.