D2 Receptors
D2 receptors are members of the dopamine receptor G-protein-coupled receptor family that also includes D1, D3, D4 and D5. They are involved in the modulation of locomotion, reward, reinforcement and memory and learning.
D2 Receptor Agonists |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 5584 | Aripiprazole |
| High affinity D2 and 5-HT1A receptor partial agonist; also 5-HT2A antagonist | |
| 6171 | MLS 1547 |
| G protein-biased D2 partial agonist | |
| 3896 | Rotigotine hydrochloride |
| D2 and D3 agonist | |
| 2773 | Sumanirole maleate |
| Selective D2 agonist | |
D2 Receptor Antagonists |
|
| Cat. No. | Product Name / Activity |
| 1003 | L-741,626 |
| High affinity D2 antagonist | |
| 4349 | Olanzapine |
| D2 antagonist; also 5-HT2A antagonist; atypical antipsychotic | |
| 4493 | Paliperidone |
| D2 antagonist; also 5-HT2A antagonist; atypical antipsychotic | |
| 4735 | Quetiapine hemifumarate |
| D2 antagonist; also 5-HT2 antagonist; atypical antipsychotic | |
| 2865 | Risperidone |
| D2 antagonist; also 5-HT2A antagonist; atypical antipsychotic | |
Other |
|
| Cat. No. | Product Name / Activity |
| 7955 | CELT-426 |
| Potent and partially selective hD2 dopamine receptor fluorescent antagonist | |
D2 receptors are members of the dopamine receptor G-protein-coupled receptor family that also includes D1, D3, D4 and D5. They are located primarily in the caudate putamen, nucleus accumbens and olfactory tubercle where they are involved in the modulation of locomotion, reward, reinforcement and memory and learning. The human D2 receptor gene has been localized to chromosome 11 (11q22-23).
External sources of pharmacological information for D2 Receptors :
Literature for D2 Receptors
Tocris offers the following scientific literature for D2 Receptors to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
Our Dopamine receptors review gives an overview of the dopamine receptor subtypes, and the receptor agonists and antagonists used to study them.
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Written by Prof David Nutt, this poster summarizes the brain circuits and neurotransmitter systems that are affected by the main classes of addictive drugs.
Request copyDownload PDFWritten by P. Skolnich et al
Our Depression poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder.
Request copyDownload PDFWritten by Anthony H.V. Schapira
Our Parkinson's disease (PD) poster summarizes the neurobiology of the disease, and highlights current therapeutic treatments for symptomatic PD.
Request copyDownload PDF