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说明： Potent, selective NK2 antagonist
生物活性 for MEN 10376
MEN 10376 is a potent and selective NK2 receptor antagonist (pA2 = 8.08, rabbit pulmonary artery). Displays > 250-fold selectivity over NK1 (pA2 = 5.66, guinea pig ileum) and NK3 (Ki > 10 mM, guinea pig brain). Active in vivo.
技术数据 for MEN 10376
| 分子量 | 1081.24 |
| 公式 | C57H68N12O10 |
| 序列 |
DYWVWWK (Modifications: Trp-3, Trp-5, Trp-6 = D-Trp, Lys-7 = C-terminal amide) |
| 储存 | Desiccate at -20°C |
| CAS Number | 135306-85-3 |
| PubChem ID | 90479818 |
| InChI Key | QQHOFZNACVKNHK-JRPYWGABSA-N |
| Smiles | [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for MEN 10376
参考文献 for MEN 10376
参考文献是支持产品生物活性的出版物。
Bartho et al (1992) Tachykininergic transmission to the circular muscle of the guinea-pig ileum: evidence for the involvement of NK2 receptors. Br.J.Pharmacol. 105 805 PMID: 1380373
Maggi et al (1991) In vivo evidence for tachykininergic transmission using a new NK-2 receptor-selective antagonist, MEN 10,376. J.Pharmacol.Exp.Ther. 257 1172 PMID: 1710662
Subramanian et al (1994) Pharmacological evidence of tachykinin-induced intracellular calcium rise in a human NK2 receptor transfected cell line. Biochem.Biophys.Res.Commun. 200 1512 PMID: 8185607
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关键词: MEN 10376, MEN 10376 supplier, Potent, selective, NK2, antagonists, Tachykinin, Receptors, Neurokinin, MEN10376, Receptor, 1632, Tocris Bioscience
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