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说明： Potent, selective NK2 antagonist
生物活性 for MEN 10627
Potent and selective competitive tachykinin NK2 receptor antagonist (pKB = 8.1 - 10.1). Displays 100- and > 1200-fold selectivity over NK1 and NK3 receptors respectively. Active in vivo.
技术数据 for MEN 10627
| 分子量 | 760.9 |
| 公式 | C38H48N8O7S |
| 序列 |
XLMDWF (Modifications: X = Dpr, Cyclized, 4-β-1-β-lactam) |
| 储存 | Desiccate at -20°C |
| CAS Number | 157351-81-0 |
| Smiles | CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)C2CNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](CC1=CNC3=C1C=CC=C3)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for MEN 10627
参考文献 for MEN 10627
参考文献是支持产品生物活性的出版物。
Lecci et al (1998) The role of tachykinin NK1 and NK2 receptors in atropine-resistant colonic propulsion in anaesthetized guinea-pigs. Br.J.Pharmacol. 124 27 PMID: 9630339
Maggi et al (1994) MEN 10,627, a novel polycyclic peptide antagonist of tachykinin NK2 receptors. J.Pharmacol.Exp.Ther. 271 1489 PMID: 7996462
Quartara et al (1996) A review of the design, synthesis and biological activity of the bicyclic hexapeptide tachykinin NK2 antagonist MEN 10627. Regul.Pept. 65 55 PMID: 8876036
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关键词: MEN 10627, MEN 10627 supplier, Potent, selective, NK2, antagonists, Tachykinin, Receptors, Neurokinin, MEN10627, Receptor, 1633, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.