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Mesopram

Cat. No. 3053 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Orally active PDE4 inhibitor
化学名： (R)-5-(4-Methoxy-3-propoxyphenyl)-5-methyl-2-oxazolidinone
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Mesopram

Mesopram is an orally active phosphodiesterase (PDE) 4 inhibitor. Inhibits Th1 cell proliferation and decreases production of IFN-γ, TNF-α, IL-10 and iNOS in vitro. Triggers ovulation and exhibits efficacy against experimental autoimmune encephalomyelitis and murine colitis in vivo.

技术数据 for Mesopram

分子量 265.31
公式 C14H19NO4
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 189940-24-7
PubChem ID 449190
InChI Key PCCPERGCFKIYIS-AWEZNQCLSA-N
Smiles O=C1O[C@@](C2=CC(OCCC)=C(OC)C=C2)(C)CN1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Mesopram

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 26.53 100
ethanol 26.53 100

制备储备液 for Mesopram

以下数据基于产品分子量 265.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.77 mL 18.85 mL 37.69 mL
5 mM 0.75 mL 3.77 mL 7.54 mL
10 mM 0.38 mL 1.88 mL 3.77 mL
50 mM 0.08 mL 0.38 mL 0.75 mL

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参考文献 for Mesopram

参考文献是支持产品生物活性的出版物。

Dinter et al (2000) The type IV phosphodiesterase specific inhibitor mesopram inhibits experimental autoimmune encephalomyelitis in rodents. J.Neuroimmunol. 108 136 PMID: 10900347

Loher et al (2003) The specific type-4 phosphodiesterase inhibitor mesopram alleviates experimental colitis in mice. J.Pharmacol.Exp.Ther. 305 549 PMID: 12606674

McKenna et al (2005) Pharmacological inhibition of phosphodiesterase 4 triggers ovulation in follicle-stimulating hormone-primed rats. Endocrinology 146 208 PMID: 15448112

If you know of a relevant reference for Mesopram, please let us know.

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关键词: Mesopram, Mesopram supplier, Orally, active, PDE4, inhibitors, inhibits, Phosphodiesterases, 3053, Tocris Bioscience

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