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Submit ReviewMesulergine hydrochloride
说明： 5-HT2A and 5-HT2C antagonist; also D2-like partial agonist
别名： CU-32-085
化学名： N'-[(8-α1,6-dimethylergolin-8-yl]-N,N-dimethylsulfamide hydrochloride
纯度： ≥99% (HPLC)
生物活性 for Mesulergine hydrochloride
Mesulergine hydrochloride is a 5-HT2A and 2C receptor antagonist (pA2 values are 9.1 for each receptor) and D2-like dopamine receptor partial agonist (Ki = 8 nM). Displays antiprolactin and antiparkinsonian effects in vivo.
技术数据 for Mesulergine hydrochloride
| 分子量 | 398.95 |
| 公式 | C18H26N4O2S.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 72786-12-0 |
| PubChem ID | 155746 |
| InChI Key | HANSYUJEPWNHIM-IVMONYBCSA-N |
| Smiles | CN2C1=CC=CC([C@]4([H])[C@@](N(C)C[C@@H](NS(=O)(N(C)C)=O)C4)([H])C3)=C1C3=C2.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Mesulergine hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 39.9 | 100 | |
| water | 1.99 | 5 温和加热 |
制备储备液 for Mesulergine hydrochloride
以下数据基于产品分子量 398.95。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.51 mL | 12.53 mL | 25.07 mL |
| 5 mM | 0.5 mL | 2.51 mL | 5.01 mL |
| 10 mM | 0.25 mL | 1.25 mL | 2.51 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
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产品说明书 for Mesulergine hydrochloride
参考文献 for Mesulergine hydrochloride
参考文献是支持产品生物活性的出版物。
Hoyer et al (1994) VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157 PMID: 7938165
Marko (1984) DA agonistic potency of two novel prolactin release-inhibiting ergolines. Eur.J.Pharmacol. 101 263 PMID: 6468500
Markstei (1983) Mesulergine and its 1,20-N,N-bidemethylated metabolite interact directly with D1- and D2-receptors. Eur.J.Pharmacol. 95 101 PMID: 6230246
If you know of a relevant reference for Mesulergine hydrochloride, please let us know.
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关键词: Mesulergine hydrochloride, Mesulergine hydrochloride supplier, 5-HT2A, 5-HT2C, 5-HT, serotonin, antagonists, D2, dopamine, partial, agonists, antiprolactin, antiParkinsonian, CU-32-085, Receptors, Non-selective, Dopamine, 1644, Tocris Bioscience
2 篇 Mesulergine hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Mesulergine hydrochloride 的部分引用包括：
Moutkine et al (2017) Heterodimers of serotonin receptor subtypes 2 are driven by 5-HT2C protomers. J Biol Chem 292 6352 PMID: 28258217
Chan et al (2015) Ergot Alkaloids (Re)generate New Leads as Antiparasitics. Neurotoxicology 9 e0004063 PMID: 26367744
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.