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Submit ReviewMethylergometrine maleate is an active metabolite of methysergide (Cat. No. 1064); uterotonic agent and oxytocic.
分子量 | 455.51 |
公式 | C20H25N3O2.C4H4O4 |
储存 | Desiccate at RT |
纯度 | ≥98% (HPLC) |
CAS Number | 57432-61-8 |
PubChem ID | 5281072 |
InChI Key | NOFOWWRHEPHDCY-DAUURJMHSA-N |
Smiles | OC(=O)\C=C/C(O)=O.[H][C@](CC)(CO)NC(=O)[C@@]1([H])CN(C)[C@]2([H])CC3=CNC4=C3C(=CC=C4)C2=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
water | 25 |
以下数据基于产品分子量 455.51。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.25 mM | 8.78 mL | 43.91 mL | 87.81 mL |
1.25 mM | 1.76 mL | 8.78 mL | 17.56 mL |
2.5 mM | 0.88 mL | 4.39 mL | 8.78 mL |
12.5 mM | 0.18 mL | 0.88 mL | 1.76 mL |
参考文献是支持产品生物活性的出版物。
MacLennan and Martin (1990) Actions of non-peptide ergot alkaloids at 5-HT1-like and 5-HT2 receptors mediating vascular smooth muscle contraction. Naunyn Schmiedebergs Arch.Pharmacol. 342 120 PMID: 2234096
Muller-Schweinitzer and Tapparelli (1986) Methylergometrine, an active metabolite of methysergide. Cephalalgia 6 35 PMID: 3698092
Pertz (1993) 5-Hydroxytryptamine (5-HT) contracts the guinea-pig isolated iliac artery via 5-HT1-like and 5-HT2 receptors. Naunyn Schmiedebergs Arch.Pharmacol. 348 558 PMID: 8133899
Merck Index 12 6147
If you know of a relevant reference for Methylergometrine maleate, please let us know.
关键词: Methylergometrine maleate, Methylergometrine maleate supplier, Active, metabolite, methysergide, Serotonin, 5-HT-, 5-Hydroxytryptamine, Receptors, 5-HT, 5-HT1, 5-HT2, antagonists, Methylergonovine, maleate, Non-selective, 0549, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 Methylergometrine maleate 的部分引用包括:
Murray et al (2011) Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol 106 925 PMID: 21653728
Chan et al (2015) Ergot Alkaloids (Re)generate New Leads as Antiparasitics. Cell Signal 9 e0004063 PMID: 26367744
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Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.