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Metyrapone

Cat. No. 3292 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： 11-β hydroxylase inhibitor
化学名： 2-Methyl-1,2-di-3-pyridinyl-1-propanone
纯度： ≥98% (HPLC)
说明书
引用文献 (3)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Metyrapone

Metyrapone is a cytochrome P450 inhibitor. Blocks glucocorticoid synthesis via inhibition of steroid 11-β hydroxylase (CYP11B1) activity (IC50 = 7.83 μM). Also inhibits CYP3A4 and cytochrome P450-mediated ω/ω-1 hydroxylase activity.

化合物库 for Metyrapone

Metyrapone is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Metyrapone

分子量 226.27
公式 C14H14N2O
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 54-36-4
PubChem ID 4174
InChI Key FJLBFSROUSIWMA-UHFFFAOYSA-N
Smiles O=C(C2=CN=CC=C2)C(C)(C)C1=CC=CN=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Metyrapone

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 2.26 10
DMSO 22.63 100

制备储备液 for Metyrapone

以下数据基于产品分子量 226.27。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.42 mL 22.1 mL 44.19 mL
5 mM 0.88 mL 4.42 mL 8.84 mL
10 mM 0.44 mL 2.21 mL 4.42 mL
50 mM 0.09 mL 0.44 mL 0.88 mL

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产品说明书 for Metyrapone

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Metyrapone

参考文献是支持产品生物活性的出版物。

Hays et al (1984) Structure-activity relationship study of the inhibition of adrenal cortical 11β-hydroxylase by new metyr. analogues. J.Med.Chem. 27 15 PMID: 6606707

Asakura and Shichi (1992) Cytochrome P450-mediated prostaglandin omega/omega-1 hydroxylase activities in porcine ciliary body epithelial cells. Exp.Eye Res. 55 377 PMID: 1426070

Park et al (2005) Structural and dynamic basis of broad substrate specificity, catalytic mechanism and inhibition of cytochrome P450 3A4. J.Am.Chem.Soc. 127 13634 PMID: 16190729

If you know of a relevant reference for Metyrapone, please let us know.

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关键词: Metyrapone, Metyrapone supplier, steroid, 11-β, 11-beta, hydroxylase, inhibitors, inhibits, Cytochrome, P450, CYP11B1, CYP3A4, omega/ω-1, omega-1, Hydroxylases, 3292, Tocris Bioscience

3 篇 Metyrapone 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Metyrapone 的部分引用包括：

Taves et al (2016) Lymphoid organs of neonatal and adult mice preferentially produce active glucocorticoids from metabolites, not precursors. Brain Behav.Immun. 57 271 PMID: 27165988

Rincón-Cortés et al (2015) Enduring good memories of infant trauma: rescue of adult neurobehavioral deficits via amygdala serotonin and corticosterone interaction. Brain Res 112 881 PMID: 25561533

Liu et al (2014) Chronic stress impairs GABAergic control of amygdala through suppressing the tonic GABAA receptor currents. Mol Brain 7 32 PMID: 24758222

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