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Submit ReviewMiglitol
说明： α-glucosidase inhibitor
别名： Bay m1009
化学名： (2R,3R,4R,5S)-1-(2-Hydroxyethyl)-2-(2-hydroxymethyl)-3,4,5-piperidinetriol
纯度： ≥98% (HPLC)
生物活性 for Miglitol
Miglitol is an inhibitor of α-glucosidase; antihyperglycemic. Suppresses postprandial hyperglycemia in vivo and reduces plasma glucose concentration in normal rats and in several animal models of diabetes. Shown to inhibit the loss of pancreatic β cells in type 2 diabetic rats. Also inhibits apoptosis and mitochondrial overproduction of reactive oxygen species in endothelial cells in vitro.
化合物库 for Miglitol
Miglitol is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Miglitol
| 分子量 | 207.22 |
| 公式 | C8H17NO5 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 72432-03-2 |
| PubChem ID | 441314 |
| InChI Key | IBAQFPQHRJAVAV-ULAWRXDQSA-N |
| Smiles | OCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Miglitol
参考文献 for Miglitol
参考文献是支持产品生物活性的出版物。
Aoki et al (2012) Miglitol, an anti-diabetic drug, inhibits oxdiative stress-induced apoptosis and mitochondrial ROS over-production in endothelial cells by enhancement of AMP-activated protein kinase. J.Pharmacol.Sci. 120 121 PMID: 23018899
Goda et al (2007) Effects of miglitol, an α-glucosidase inhibitor, on glycaemic staus and histopathological changes in islets in non-obese, non-Ins-dependent diabetic Goto-Kakizaki rats. Br.J.Nutr. 98 702 PMID: 17537288
Sels et al (1999) Miglitol, a new α-glucosidase inhibitor. Expert.Opin.Pharmacother. 1 149 PMID: 11249557
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关键词: Miglitol, Miglitol supplier, Baym1009, antidiabetic, alpha, a, α-glucosidase, inhibitors, inhibits, Bay, m1009, Glycosylases, 4985, Tocris Bioscience
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