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说明： PDE3 inhibitor
化学名： 1,6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile
纯度： ≥98% (HPLC)
生物活性 for Milrinone
Milrinone is a potent cAMP phosphodiesterase inhibitor (IC50 = 56 nM for inhibition of PDE III). Has inotropic and vasodilator effects following oral or intravenous administration in vivo.
技术数据 for Milrinone
| 分子量 | 211.22 |
| 公式 | C12H9N3O |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 78415-72-2 |
| PubChem ID | 4197 |
| InChI Key | PZRHRDRVRGEVNW-UHFFFAOYSA-N |
| Smiles | CC1=C(C=C(C#N)C(=O)N1)C1=CC=NC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Milrinone
参考文献 for Milrinone
参考文献是支持产品生物活性的出版物。
Alousi et al (1983) Characterization of the cardiotonic effects of milrinone, a new and potent cardiac bipyridine, on isolated tissues from several animal species. J.Cardiovasc.Pharmacol. 5 804 PMID: 6195468
Shahid et al (1991) The presence of five cyclic nucleotide phosphodiesterase isoenzyme activities in bovine tracheal smooth muscle and the functional effects of selective inhibitors. Br.J.Pharmacol. 104 471 PMID: 1665737
Tang et al (1994) Photoaffinity labelling of cyclic GMP-inhibited phosphodiesterase (PDE III) in human and rat platelets and rat tissues: effects of phosphodiesterase inhibitors. Eur.J.Pharmacol. 268 105 PMID: 7925608
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关键词: Milrinone, Milrinone supplier, PDE3, inhibitors, inhibits, Phosphodiesterases, 1504, Tocris Bioscience
2 篇 Milrinone 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Milrinone 的部分引用包括：
Ørstavik et al (2015) The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium. Dent Res J (Isfahan) 10 e0115547 PMID: 25738589
Roberts et al (2010) Thrombospondin-1 induces platelet activation through CD36-dependent inhibition of the cAMP/protein kinase A signaling cascade. Blood 116 4297 PMID: 20664056
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