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说明： PDE3 inhibitor
化学名： 1,6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile
纯度： ≥98% (HPLC)
生物活性 for Milrinone
Milrinone is a potent cAMP phosphodiesterase inhibitor (IC50 = 56 nM for inhibition of PDE III). Has inotropic and vasodilator effects following oral or intravenous administration in vivo.
技术数据 for Milrinone
| 分子量 | 211.22 |
| 公式 | C12H9N3O |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 78415-72-2 |
| PubChem ID | 4197 |
| InChI Key | PZRHRDRVRGEVNW-UHFFFAOYSA-N |
| Smiles | CC1=C(C=C(C#N)C(=O)N1)C1=CC=NC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Milrinone
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 21.12 | 100 |
制备储备液 for Milrinone
以下数据基于产品分子量 211.22。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.73 mL | 23.67 mL | 47.34 mL |
| 5 mM | 0.95 mL | 4.73 mL | 9.47 mL |
| 10 mM | 0.47 mL | 2.37 mL | 4.73 mL |
| 50 mM | 0.09 mL | 0.47 mL | 0.95 mL |
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产品说明书 for Milrinone
参考文献 for Milrinone
参考文献是支持产品生物活性的出版物。
Alousi et al (1983) Characterization of the cardiotonic effects of milrinone, a new and potent cardiac bipyridine, on isolated tissues from several animal species. J.Cardiovasc.Pharmacol. 5 804 PMID: 6195468
Shahid et al (1991) The presence of five cyclic nucleotide phosphodiesterase isoenzyme activities in bovine tracheal smooth muscle and the functional effects of selective inhibitors. Br.J.Pharmacol. 104 471 PMID: 1665737
Tang et al (1994) Photoaffinity labelling of cyclic GMP-inhibited phosphodiesterase (PDE III) in human and rat platelets and rat tissues: effects of phosphodiesterase inhibitors. Eur.J.Pharmacol. 268 105 PMID: 7925608
If you know of a relevant reference for Milrinone, please let us know.
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关键词: Milrinone, Milrinone supplier, PDE3, inhibitors, inhibits, Phosphodiesterases, 1504, Tocris Bioscience
2 篇 Milrinone 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Milrinone 的部分引用包括：
Ørstavik et al (2015) The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium. Dent Res J (Isfahan) 10 e0115547 PMID: 25738589
Roberts et al (2010) Thrombospondin-1 induces platelet activation through CD36-dependent inhibition of the cAMP/protein kinase A signaling cascade. Blood 116 4297 PMID: 20664056
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