Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit Review(-)-Cannabidiol
说明： Natural cannabinoid; GPR55 antagonist, weak CB1 antagonist, CB2 inverse agonist and AMT inhibitor
别名： CBD
化学名： 2-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol
纯度： ≥99% (HPLC)
生物活性 for (-)-Cannabidiol
(-)-Cannabidiol is a non-psychotropic constituent of cannabis that is anticonvulsive, antihyperalgesic and neuroprotective in vivo. GPR55 and weak CB1 antagonist (IC50 values are 0.445 and 3.35 μM), CB2 receptor inverse agonist and inhibitor of anandamide uptake (IC50 = 27.5 μM). Also inhibits FABPs and a weak agonist at TRP vanilloid receptors (EC50 = 3.5 μM).
技术数据 for (-)-Cannabidiol
| 分子量 | 314.47 |
| 公式 | C21H30O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 13956-29-1 |
| PubChem ID | 12302390 |
| InChI Key | QHMBSVQNZZTUGM-ROUUACIJSA-N |
| Smiles | CCCCCC1=CC(O)=C([C@H]2C=C(C)CC[C@H]2C(C)=C)C(O)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for (-)-Cannabidiol
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| ethanol | 23.59 | 75 | |
| DMSO | 23.59 | 75 |
制备储备液 for (-)-Cannabidiol
以下数据基于产品分子量 314.47。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.75 mM | 4.24 mL | 21.2 mL | 42.4 mL |
| 3.75 mM | 0.85 mL | 4.24 mL | 8.48 mL |
| 7.5 mM | 0.42 mL | 2.12 mL | 4.24 mL |
| 37.5 mM | 0.08 mL | 0.42 mL | 0.85 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
产品说明书 for (-)-Cannabidiol
参考文献 for (-)-Cannabidiol
参考文献是支持产品生物活性的出版物。
Costa et al (2004) Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation. Br.J.Pharmacol. 143 247 PMID: 15313881
Petitet et al (1998) Complex pharmacology of natural cannabinoids: evidence for partial agonist activity of Δ9-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptors. Life Sci. 63 PL1 PMID: 9667767
Ryberg et al (2007) The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 152 1092 PMID: 17876302
Thomas et al (2007) Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro. Br.J.Pharmacol. 150 613 PMID: 17245363
Deutsch (2016) A personal retrospective: Elevating Anandamide (AEA) by targeting fatty acid amide hydrolase (FAAH) and the fatty acid binding proteins (FABPs). Front.Pharmacol. 7 370 PMID: 27790143
If you know of a relevant reference for (-)-Cannabidiol, please let us know.
按标靶查看相关产品
按产品操作查看相关产品
关键词: (-)-Cannabidiol, (-)-Cannabidiol supplier, Natural, cannabinoids, AMT, inhibitors, inhibits, GPR55, antagonists, weak, CB1, CB2, inverse, agonists, Anandamide, Transporters, Monoamine, Neurotransmitter, Non-Selective, Receptors, cb2r, cb1r, FABP, FABPs, fatty, acid, binding, proteins, CBD, Cannabinoid, Non-selective, Cannabinoids, Fatty, Acid, Binding, Proteins, 1570, Tocris Bioscience
5 篇 (-)-Cannabidiol 的引用文献
引用文献是使用了 Tocris 产品的出版物。 (-)-Cannabidiol 的部分引用包括：
Esposito et al (2011) Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement. Proc Natl Acad Sci U S A 6 e28668 PMID: 22163051
Whyte et al (2009) The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo. PLoS One 106 16511 PMID: 19805329
Rodríguez-Muñoz et al (2018) Cannabidiol enhances MOR antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor. Mol Brain 11 51 PMID: 30223868
Hamtiaux et al (2011) Increasing antiproliferative properties of endocannabinoids in N1E-115 neuroblastoma cells through inhibition of their metabolism. PLoS One 6 e26823 PMID: 22046372
Panja et al (2019) Paraneoplastic cerebellar degeneration: Yo antibody alters mitochondrial calcium buffering capacity. Neuropathol Appl Neurobiol 45 141 PMID: 29679372
您是否知道使用了 Tocris (-)-Cannabidiol 的优秀论文？ 请告知我们.
(-)-Cannabidiol 的评论
目前没有该产品的评论。 Be the first to review (-)-Cannabidiol and earn rewards!
Have you used (-)-Cannabidiol?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.