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MIRA-1

Cat. No. 3362 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Restores mutant p53 activity; proapoptotic
化学名： 1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione
说明书
引用文献 (1)
评论
文献 (2)
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for MIRA-1

MIRA-1 is a restores wild-type conformation, function and DNA binding activity to mutant p53. Induces p53 transcriptional transactivation of p21, MDM2 and PUMA, and promotes tumor cell death by apoptosis in a mutant p53-dependent manner in vitro (IC50 = 10μM).

技术数据 for MIRA-1

分子量 183.16
公式 C8H9NO4
储存 Store at +4°C
CAS Number 72835-26-8
PubChem ID 227681
InChI Key YXEWPGYLMHXLPS-UHFFFAOYSA-N
Smiles O=C(N1COC(CC)=O)C=CC1=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for MIRA-1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 18.32 100
ethanol 18.32 100

制备储备液 for MIRA-1

以下数据基于产品分子量 183.16。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 5.46 mL 27.3 mL 54.6 mL
5 mM 1.09 mL 5.46 mL 10.92 mL
10 mM 0.55 mL 2.73 mL 5.46 mL
50 mM 0.11 mL 0.55 mL 1.09 mL

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参考文献 for MIRA-1

参考文献是支持产品生物活性的出版物。

Bykov et al (2005) Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs. J.Biol.Chem. 280 30384 PMID: 15998635

Wiman (2006) Strategies for therapeutic targeting of the p53 pathway in cancer. Cell Death Differ. 13 921 PMID: 16557267

Kumar et al (2007) p53 in breast cancer: mutation and countermeasures. Front.Biosci. 12 4168 PMID: 17485365

If you know of a relevant reference for MIRA-1, please let us know.

按标靶查看相关产品

关键词: MIRA-1, MIRA-1 supplier, Restores, mutant, p53, activity, proapoptotic, Transcription, Factors, 3362, Tocris Bioscience

1 篇 MIRA-1 的引用文献

引用文献是使用了 Tocris 产品的出版物。 MIRA-1 的部分引用包括：

Saha et al (2014) Small molecule MIRA-1 induces in vitro and in vivo anti-myeloma activity and synergizes with current anti-myeloma agents. Br J Cancer 110 2224 PMID: 24691427

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Pathways for MIRA-1

p53 Signaling Pathway

p53 Signaling Pathway

p53 signaling plays an important role in the co-ordination of the cellular response different types of stress such as DNA damage and hypoxia. The downstream signals lead to apoptosis, senescence and cell cycle arrest.