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Miro1 Reducer

Cat. No. 7091 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Promotes mitochondrial Rho GTPase 1 (Miro1) degradation
化学名： N-(3-Fluorophenyl)-N'-[4-[[6-(1H-imidazol-1-yl)-4-pyrimidinyl]amino]phenyl]urea hydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Miro1 Reducer

Miro1 Reducer is a promotes proteasomal degradation of Miro1 (mitochondrial Rho GTPase 1). Reduces Miro1 levels in fibroblasts from Parkinson's disease (PD) patients (IC50 = 7.8 μM). Exhibits no significant effect on related outer mitochondrial membrane protein Mitofusin. Reduces stress-induced degeneration of dopaminergic neurons derived from PD patient iPSCs. Rescues age-dependent neuronal loss and prolongs lifespan in fly PD models.

化合物库 for Miro1 Reducer

Miro1 Reducer is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Miro1 Reducer

分子量 425.85
公式 C20H16FN7O.HCl
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2624336-91-8
InChI Key UKXRHSHXZHFFTA-UHFFFAOYSA-N
Smiles FC1=CC=CC(NC(NC2=CC=C(C=C2)NC3=CC(N4C=CN=C4)=NC=N3)=O)=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Miro1 Reducer

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 42.58 100

制备储备液 for Miro1 Reducer

以下数据基于产品分子量 425.85。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.35 mL 11.74 mL 23.48 mL
5 mM 0.47 mL 2.35 mL 4.7 mL
10 mM 0.23 mL 1.17 mL 2.35 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

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参考文献 for Miro1 Reducer

参考文献是支持产品生物活性的出版物。

Hsieh et al (2019) Miro1 marks Parkinson's disease subset and Miro1 reducer rescues reuron ross in Parkinson's models. Cell Metab. 30 1131 PMID: 31564441

If you know of a relevant reference for Miro1 Reducer, please let us know.

按标靶查看相关产品

关键词: Miro1 Reducer, Miro1 Reducer supplier, 1360287-51-9, miro1, proteasomal, degradation, reducer, reduces, mitochondrial, Rho, GTPase, 1, RHOT1, 7091, Tocris Bioscience

1 篇 Miro1 Reducer 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Miro1 Reducer 的部分引用包括：

Manfred et al (2022) A Protumorigenic mDia2-MIRO1 Axis Controls Mitochondrial Positioning and Function in Cancer-Associated Fibroblasts. Cancer Res 82 3701-3717 PMID: 35997559

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