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说明： Dynamin inhibitor
化学名： Tetradecyltrimethylammonium bromide
生物活性 for MitMAB
MitMAB is a dynamin inhibitor; inhibits the GTPase activity of dynamin I (Ki = 940 nM; IC50 = 3.1 μM). Targets the dynamin-phospholipid interaction. Inhibits receptor-mediated endocytosis of epidermal growth factor (EGF) in non-neuronal cells; also inhibits synaptic vesicle endocytosis. Displays dynamin I-inhibitory activity similar to OctMAB (Cat. No. 4225).
技术数据 for MitMAB
| 分子量 | 336.39 |
| 公式 | C17H38BrN |
| 储存 | Desiccate at RT |
| CAS Number | 1119-97-7 |
| PubChem ID | 14250 |
| InChI Key | CXRFDZFCGOPDTD-UHFFFAOYSA-M |
| Smiles | C[N+](C)(C)CCCCCCCCCCCCCC.[Br-] |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for MitMAB
参考文献 for MitMAB
参考文献是支持产品生物活性的出版物。
Hill et al (2004) Long chain amines and long chain ammonium salts as novel inhibitors of dynamin GTPase activity. Bioorg.Med.Chem.Lett. 14 3275 PMID: 15149689
Quan et al (2007) Myristyl trimethyl ammonium bromide and octadecyl trimethyl ammonium bromide are surface-active small molecule dynamin inhibitors that block endocytosis mediated by dynamin I or dynamin II. Mol.Pharmacol. 72 1425 PMID: 17702890
de Beco et al (2009) Endocytosis is required for E-cadherin redistribution at mature adherens junctions. Proc.Natl.Acad.Sci. 106 7010
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关键词: MitMAB, MitMAB supplier, dynamin, I, II, inhibitors, inhibits, gtpase, endocytosis, MitMAB, Mitosis, Dynamin, 4224, Tocris Bioscience
MitMAB 的评论
平均评分: 5 (Based on 1 Review.)
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Apoptosis was induced by MitMAB in PC3 cells.
By
Anonymous on 02/11/2019
种属： Human
Apoptosis was induced by MitMAB in PC3 cells. The figure shows the results from DAPI staining obtained via EVOSTM Floid Florescence Microscope X80 magnification.
