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Submit ReviewMitoxantrone dihydrochloride
说明： Topoisomerase II inhibitor; immunosuppressive and antineoplastic agent
化学名： 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride
纯度： ≥98% (HPLC)
生物活性 for Mitoxantrone dihydrochloride
Mitoxantrone dihydrochloride is a type II DNA topoisomerase inhibitor. Disrupts DNA synthesis and repair and induces damage by DNA cross-linking. Also inhibits PIM1 kinase (IC50 = 51 nM). Immunomodulatory, antineoplastic and chemotherapeutic agent. Also USP11 inhibitor (IC50= 3.15 μM). Induces cell death of pancreatic cancer cell lines expressing wild-type BRCA2.
技术数据 for Mitoxantrone dihydrochloride
| 分子量 | 517.4 |
| 公式 | C22H28N4O6.2HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 70476-82-3 |
| PubChem ID | 51082 |
| InChI Key | ZAHQPTJLOCWVPG-UHFFFAOYSA-N |
| Smiles | O=C2C3=C(C(O)=CC=C3O)C(C1=C(NCCNCCO)C=CC(NCCNCCO)=C12)=O.Cl.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Mitoxantrone dihydrochloride
参考文献 for Mitoxantrone dihydrochloride
参考文献是支持产品生物活性的出版物。
Scott and Figgit (2004) Mitoxantrone: a review of its uses in multiple sclerosis. CNS Drugs. 18 379 PMID: 15089110
Crespi et al (1986) Mitoxantrone affects topoisomerase activities in human breast cancer cells. Biochem.Biophys.Res.Comm. 136 521 PMID: 3010982
Wan et al (2013) A new target for an old drug: identifying mitoxan. as a nanomolar inhibitor of PIM1 kinase via kinome-wide selectivity modeling. J.Med.Chem. 56 2619 PMID: 23442188
Burkhart et al (2013) Mitoxantrone targets human ubiquitin-specific peptidase 11 (USP11) and is a potent inhibitor of pancreatic cancer cell survival. Mol.Cancer Res. 11 901 PMID: 23696131
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关键词: Mitoxantrone dihydrochloride, Mitoxantrone dihydrochloride supplier, topoisomerase, II, inhibitors, inhibits, DNA, type, antitumor, immunosuppressant, synthesis, repair, PIM1, kinase, USP11, ubiquitin, specific, peptidase, 11, chemotherapeutics, Topoisomerase, Pim, Kinase, Deubiquitinating, Enzymes, 4250, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Mitoxantrone hydrochloride, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov
2 篇 Mitoxantrone dihydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Mitoxantrone dihydrochloride 的部分引用包括：
Zhang (2017) The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes PacT. Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors. Mol Cancer Ther 16 1021 PMID: 28265007
Kathawala et al (2015) The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated PacT. resistance: a preclinical and pharmacokinetic study. Oncotarget 6 510 PMID: 25402202
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Paclitaxel, docetaxel, vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone screen for Human epidermal carcinoma.
By
Anonymous on 11/17/2019
分析类型： In Vitro
种属： Human
细胞系/组织： Human epidermal carcinoma cell line
Human epidermal carcinoma cell line was treated with Paclitaxel, docetaxel,vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone which purchased from Tocris Bioscience.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Huntington's Disease Research Product Guide
This product guide provides a background to Huntington's disease research and lists around 100 products for the study of:
- Somatic Instability
- Proteolysis and Inclusion Bodies
- Transcriptional Dysregulation
- Mitochondrial Dysfunction
- Nuclear-Cytoplasmic Transport Interference
- Excitotoxicity
- Stem Cells
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.