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说明： Potent and selective CB1 antagonist
化学名： 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(3-pyridinylmethyl)-1H-pyrazole-3-carboxamide
纯度： ≥99% (HPLC)
生物活性 for MJ 15
MJ 15 is a potent and selective CB1 receptor antagonist (Ki = 27.2 pM, IC50 = 118.9 pM for rat CB1 receptors). Exhibits potency in obesity and hyperlipidemia models; inhibits food intake and increases in body weight in diet-induced obese rats and mice.
许可信息
Sold under licence.
技术数据 for MJ 15
| 分子量 | 471.77 |
| 公式 | C23H17Cl3N4O |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 944154-76-1 |
| PubChem ID | 59377482 |
| InChI Key | PJEIKJFNEFJFLA-UHFFFAOYSA-N |
| Smiles | ClC1=CC(Cl)=CC=C1N2C(C3=CC=C(Cl)C=C3)=C(C)C(C(NCC4=CC=CN=C4)=O)=N2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for MJ 15
参考文献 for MJ 15
参考文献是支持产品生物活性的出版物。
Chen et al (2010) Novel, selective antagonist of the cannabinoid CB1 receptor, MJ15, with prominent anti-obesity effect in rodent models. Eur.J.Pharmacol. 637 178 PMID: 20380831
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关键词: MJ 15, MJ 15 supplier, MJ15, CB1, receptors, antagonist, cannabinoid, 1, antagonists, obesity, dyslipidemia, dyslipidaemia, Receptors, 4063, Tocris Bioscience
2 篇 MJ 15 的引用文献
引用文献是使用了 Tocris 产品的出版物。 MJ 15 的部分引用包括：
Tan and Cao (2018) Cannabinoid WIN-55,212-2 mesylate inhibits tumor necrosis factor-α-induced expression of nitric oxide synthase in dorsal root ganglion neurons. Int J Mol Med 42 919 PMID: 29786105
Kong et al (2016) Cannabinoid WIN-55,212-2 mesylate inhibits ADAMTS-4 activity in human osteoarthritic articular chondrocytes by inhibiting expression of syndecan-1. J Virol 13 4569 PMID: 27082728
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