MK 571

Cat. No. 2338 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent CysLT₁ (LTD₄) inverse agonist. Also MRP1 inhibitor

别名： L-660711

化学名： 3-[[[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]propanoic acid

引用文献 (5)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for MK 571

MK 571 is a potent CysLT₁ (LTD₄) leukotriene receptor inverse agonist (EC₅₀ = 1.3 nM). Antagonizes LTD₄-induced contractions of guinea pig trachea and ileum (pA₂ values are 9.4 and 10.5 respectively). Also inhibitor of multidrug resistance protein-1 (MRP1) mediated transport; in vitro augments the effects of cytotoxic agents on malignant cells.

技术数据 for MK 571

分子量	515.09
公式	C₂₆H₂₇ClN₂O₃S₂
储存	Store at -20°C
CAS Number	115104-28-4
PubChem ID	5281888
InChI Key	AXUZQJFHDNNPFG-UXBLZVDNSA-N
Smiles	ClC1=CC=C(C=CC(/C=C/C3=CC(C(SCCC(O)=O)SCCC(N(C)C)=O)=CC=C3)=N2)C2=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for MK 571

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	51.51	100

制备储备液 for MK 571

以下数据基于产品分子量 515.09。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.94 mL	9.71 mL	19.41 mL
5 mM	0.39 mL	1.94 mL	3.88 mL
10 mM	0.19 mL	0.97 mL	1.94 mL
50 mM	0.04 mL	0.19 mL	0.39 mL

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产品说明书 for MK 571

分析证书/产品说明书

化学品安全技术说明书

参考文献 for MK 571

参考文献是支持产品生物活性的出版物。

Vellenga et al (1999) Interleukin-6 production by activated human monocytic cells is enhanced by MK-571, a specific inhibitor of the multi-drug resistance protein-1. Br.J.Pharmacol. 127 441 PMID: 10385244

Dupre et al (2004) Inverse agonist activity of selected ligands of the cysteinyl-leukotriene receptor 1. J.Pharmacol.Exp.Ther. 309 102 PMID: 14718577

Blain and Sirois (2000) Involvement of LTD4 in allergic pulmonary inflammation in mice: modulation by cysLT₁ antagonist MK-571. Prost.Leuko.Essent.Fatty Acids 62 361

If you know of a relevant reference for MK 571, please let us know.

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关键词: MK 571, MK 571 supplier, Potent, CysLT1, LTD4, inverse, agonists, MRP, inhibitors, inhibits, Receptors, leukotrienes, eicosanoids, MDR, Resistance, Protein, Multidrug, Transporters, MK571, L660711, L-660711, Leukotriene, and, Related, 2338, Tocris Bioscience