MK 571

Pricing Availability   Qty
说明: Potent CysLT1 (LTD4) inverse agonist. Also MRP1 inhibitor
别名: L-660711
化学名: 3-[[[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]propanoic acid
纯度: ≥98% (HPLC)
说明书
引用文献 (5)
评论

生物活性 for MK 571

MK 571 is a potent CysLT1 (LTD4) leukotriene receptor inverse agonist (EC50 = 1.3 nM). Antagonizes LTD4-induced contractions of guinea pig trachea and ileum (pA2 values are 9.4 and 10.5 respectively). Also inhibitor of multidrug resistance protein-1 (MRP1) mediated transport; in vitro augments the effects of cytotoxic agents on malignant cells.

技术数据 for MK 571

分子量 515.09
公式 C26H27ClN2O3S2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 115104-28-4
PubChem ID 5281888
InChI Key AXUZQJFHDNNPFG-UXBLZVDNSA-N
Smiles ClC1=CC=C(C=CC(/C=C/C3=CC(C(SCCC(O)=O)SCCC(N(C)C)=O)=CC=C3)=N2)C2=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for MK 571

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 51.51 100

制备储备液 for MK 571

以下数据基于产品分子量 515.09。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.94 mL 9.71 mL 19.41 mL
5 mM 0.39 mL 1.94 mL 3.88 mL
10 mM 0.19 mL 0.97 mL 1.94 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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产品说明书 for MK 571

分析证书/产品说明书
选择另一批次:

参考文献 for MK 571

参考文献是支持产品生物活性的出版物。

Vellenga et al (1999) Interleukin-6 production by activated human monocytic cells is enhanced by MK-571, a specific inhibitor of the multi-drug resistance protein-1. Br.J.Pharmacol. 127 441 PMID: 10385244

Dupre et al (2004) Inverse agonist activity of selected ligands of the cysteinyl-leukotriene receptor 1. J.Pharmacol.Exp.Ther. 309 102 PMID: 14718577

Blain and Sirois (2000) Involvement of LTD4 in allergic pulmonary inflammation in mice: modulation by cysLT1 antagonist MK-571. Prost.Leuko.Essent.Fatty Acids 62 361


If you know of a relevant reference for MK 571, please let us know.

关键词: MK 571, MK 571 supplier, Potent, CysLT1, LTD4, inverse, agonists, MRP, inhibitors, inhibits, Receptors, leukotrienes, eicosanoids, MDR, Resistance, Protein, Multidrug, Transporters, MK571, L660711, L-660711, Leukotriene, and, Related, 2338, Tocris Bioscience

5 篇 MK 571 的引用文献

引用文献是使用了 Tocris 产品的出版物。 MK 571 的部分引用包括:

Hill et al (2013) Characterisation of the roles of ABCB1, ABCC1, ABCC2 and ABCG2 in the transport and pharmacokinetics of actinomycin D in vitro and in vivo. Am J Physiol Heart Circ Physiol 85 29 PMID: 23063411

Schnúr et al (2019) Phosphorylation-dependent modulation of CFTR macromolecular signalling complex activity by cigarette smoke condensate in airway epithelia. Sci Rep 9 12706 PMID: 31481727

Wright et al (2019) Pranlukast is a novel small molecule activator of the two-pore domain potassium channel TREK2. Biochem Biophys Res Commun 520 35 PMID: 31564414

Stott et al (2015) A primary fish gill cell culture model to assess pharmaceutical uptake and efflux: evidence for passive and facilitated transport. Antimicrob Agents Chemother 159 127 PMID: 25544062


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