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ML 145

Cat. No. 4172 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： GPR35 antagonist
化学名： 2-Hydroxy-4-[4-(5Z)-5-[(E)-2-methyl-3-phenylprop-2-enylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoylamino]benzoic acid
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ML 145

ML 145 is a selective antagonist for the GPR35 orphan receptor GPCR (IC50 = 20.1 nM). Over 1000-fold more selective for GPR35 compared to GPR55 antagonists.

技术数据 for ML 145

分子量 482.57
公式 C24H22N2O5S2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1164500-72-4
PubChem ID 2286812
InChI Key COFMYJWNXSFLKQ-QIROLCGISA-N
Smiles O=C(NC3=CC=C(C(O)=O)C(O)=C3)CCCN2C(/C(SC2=S)=C/C(C)=C/C1=CC=CC=C1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ML 145

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 48.26 100

制备储备液 for ML 145

以下数据基于产品分子量 482.57。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.07 mL 10.36 mL 20.72 mL
5 mM 0.41 mL 2.07 mL 4.14 mL
10 mM 0.21 mL 1.04 mL 2.07 mL
50 mM 0.04 mL 0.21 mL 0.41 mL

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产品说明书 for ML 145

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for ML 145

参考文献是支持产品生物活性的出版物。

Heynen-Genel et al (2010) Antagonists for the orphan receptor GPR35. Probe Reports from the Molecular Libraries Program NBK5070

Jenkins et al (2012) Antagonists of GPR35 display high species ortholog selectivity and varying modes of action. J.Pharmacol.Exp.Ther. 343 683 PMID: 22967846

If you know of a relevant reference for ML 145, please let us know.

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关键词: ML 145, ML 145 supplier, ML145, Supplier, orphan, receptor, antagonist, antagonists, GPR35, 4172, Tocris Bioscience

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