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Submit ReviewML 161 is an inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50 = 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). Thought to act allosterically. Also inhibits thrombin-induced platelet activation.
分子量 | 361.23 |
公式 | C17H17BrN2O2 |
储存 | Store at +4°C |
纯度 | ≥98% (HPLC) |
CAS Number | 423735-93-7 |
PubChem ID | 1048267 |
InChI Key | DFOVLSMXPWPCFH-UHFFFAOYSA-N |
Smiles | O=C(NC2=CC(NC(CCC)=O)=CC=C2)C1=CC=CC=C1Br |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
参考文献是支持产品生物活性的出版物。
Dockendorff et al (2012) Discovery of 1,3-diaminobenzenes as selective inhibitors of platelet activation at the PAR1 receptor. ACS Med.Chem.Lett. 3 232 PMID: 22408714
关键词: ML 161, ML 161 supplier, ML161, inhibitors, inhibits, protease-activated, proteinase-activated, receptors, par1, Protease-Activated, Receptors, 4570, Tocris Bioscience
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