ML 190

Cat. No. 4866 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective κ opioid receptor antagonist

化学名： N-[3-[4-(4-Methoxyphenyl)-1-piperazinyl]propyl]-1-methyl-6-oxopyrido[2,3-e]pyrrolo[1,2-a]pyrazine-5(6H)-acetamide

纯度： ≥98% (HPLC)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for ML 190

ML 190 is a selective κ opioid receptor (KOP) antagonist (IC₅₀ = 120 nM in a β-arrestin assay); displays >267-fold selectivity over μ and δ opioid receptors.

技术数据 for ML 190

分子量	488.58
公式	C₂₇H₃₂N₆O₃
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	1355244-02-8
PubChem ID	44665680
InChI Key	PMTIWRPLQBVEMR-UHFFFAOYSA-N
Smiles	O=C(CN4C(C3=CC=CN3C5=C4N=CC=C5C)=O)NCCCN(CC2)CCN2C1=CC=C(OC)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ML 190

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	9.77	20

制备储备液 for ML 190

以下数据基于产品分子量 488.58。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.2 mM	10.23 mL	51.17 mL	102.34 mL
1 mM	2.05 mL	10.23 mL	20.47 mL
2 mM	1.02 mL	5.12 mL	10.23 mL
10 mM	0.2 mL	1.02 mL	2.05 mL

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产品说明书 for ML 190

分析证书/产品说明书

化学品安全技术说明书

参考文献 for ML 190

参考文献是支持产品生物活性的出版物。

Frankowski et al (2012) Discovery of small molecule kappa opioid receptor agonist and antagonist chemotypes through a HTS and hit refinement strategy. ACS Chem.Neurosci. 3 221 PMID: 22737280

Hedrick et al (2011) Antagonist for the kappa opioid receptor. Probe Reports from the NIH Molecular Libraries Pro PMID: 22091479

If you know of a relevant reference for ML 190, please let us know.

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关键词: ML 190, ML 190 supplier, ML190, selective, κ-opioid, kappa-opioid, antagonists, KOP, Receptors, OP, Kappa, Opioid, 4866, Tocris Bioscience

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