主页 / 药理学 / GPCRs / 7-TM Receptors / GPR55 / GPR55 Antagonists / ML 193

ML 193

Cat. No. 4860 3 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent, selective GPR55 antagonist
别名： CID 1261822
化学名： N-[4-[[(3,4-Dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide
纯度： ≥98% (HPLC)
说明书
引用文献 (3)
评论 (1)
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ML 193

ML 193 is a selective GPR55 antagonist (IC50 = 221 nM). Exhibits >27-, >145- and >145-fold selectivity for GPR55 over CB1, GPR35 and CB2, respectively. Inhibits ERK signaling in vitro.

技术数据 for ML 193

分子量 527.59
公式 C28H25N5O4S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 713121-80-3
PubChem ID 1261822
InChI Key HTSLEZOTMYUPLU-UHFFFAOYSA-N
Smiles CC2=CC(C)=CC1=C(C(NC4=CC=C(S(=O)(NC5=C(C)C(C)=NO5)=O)C=C4)=O)C=C(C3=CC=CC=N3)N=C12

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ML 193

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 52.76 100

制备储备液 for ML 193

以下数据基于产品分子量 527.59。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.9 mL 9.48 mL 18.95 mL
5 mM 0.38 mL 1.9 mL 3.79 mL
10 mM 0.19 mL 0.95 mL 1.9 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

产品说明书 for ML 193

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for ML 193

参考文献是支持产品生物活性的出版物。

Heynen-Genel et al (2010) Screening for selective ligands for GPR55 - antagonists. Probe Reports from the NIH Molecular Libraries Program PMID: 22091481

Kotsikorou et al (2013) Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands. Biochemistry 52 9456 PMID: 24274581

If you know of a relevant reference for ML 193, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 GPR55 Antagonists

关键词: ML 193, ML 193 supplier, ML193, CID1261822, GPR55, agonists, potent, selective, agonism, cannabinoids, CID, 1261822, 4860, Tocris Bioscience

3 篇 ML 193 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ML 193 的部分引用包括：

Saliba et al (2018) Anti-neuroinflammatory effects of GPR55 antagonists in LPS-activated primary microglial cells. J Neuroinflammation 15 322 PMID: 30453998

Alharris et al (2019) Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget 10 45 PMID: 30713602

Drzazga (2017) Lysophosphatidylcholine elicits intracellular calcium signaling in GPR55-dependent manner. Biochem Biophys Res Commun 489 243 PMID: 28552523

您是否知道使用了 Tocris ML 193 的优秀论文？ 请告知我们.

ML 193 的评论

平均评分: 5 (Based on 1 Review.)

5 星
100%
4 星
0%
3 星
0%
2 星
0%
1 星
0%

Have you used ML 193?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


ML-193 effect on microglia immunal function.
By Anonymous on 09/21/2019
分析类型： In Vitro
种属： Mouse
细胞系/组织： Hippocampus

ML-193 was used to study the effect of receptor GPR-55 on release of prostaglandin E2 from hippocampal microglia. ML-193 triggered highly significant lowering of the prostaglandin release compared to control; however, difference between the effects of four tested doses was non-significant (see figure).

Soluble in DMSO, perfectly mixes with artificial cerebro-spinal fluid.

review image

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Cannabinoid Receptor Ligands Scientific Review

Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.