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ML 204

Cat. No. 4732 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective TRPC4 inhibitor
化学名： 4-Methyl-2-(1-piperidinyl)quinoline
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ML 204

ML 204 is a blocker of TRPC4 channels (IC50 values are 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively). Exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5; displays no significant activity at TRPV1, TRPV3, TRPA1 and TRPM8 channels at concentrations up to 22 μM.

化合物库 for ML 204

ML 204 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for ML 204

分子量 226.32
公式 C15H18N2
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 5465-86-1
PubChem ID 230710
InChI Key USYRQXDHKXGTCK-UHFFFAOYSA-N
Smiles CC2=CC(N3CCCCC3)=NC1=CC=CC=C12

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ML 204

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 22.63 100
1eq. HCl 5.66 25 温和加热

制备储备液 for ML 204

以下数据基于产品分子量 226.32。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.42 mL 22.09 mL 44.19 mL
5 mM 0.88 mL 4.42 mL 8.84 mL
10 mM 0.44 mL 2.21 mL 4.42 mL
50 mM 0.09 mL 0.44 mL 0.88 mL

Molarity Calculator

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Dilution Calculator

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参考文献 for ML 204

参考文献是支持产品生物活性的出版物。

Miller et al (2011) Novel chemical inhibitor of TRPC4 channels. Probe Reports from the Molecular Libraries Program PMID: 22049577

Miller et al (2011) Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/5 ion channels. J.Biol.Chem. 286 33436 PMID: 21795696

If you know of a relevant reference for ML 204, please let us know.

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关键词: ML 204, ML 204 supplier, ML204, TRPC4, blockers, transient, receptor, potential, channels, canonical, TRPC, 4732, Tocris Bioscience

1 篇 ML 204 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ML 204 的部分引用包括：

Gertjan et al (2021) Gut bacteria-derived 5-hydroxyindole is a potent stimulant of intestinal motility via its action on L-type calcium channels. PLoS Biol 19 e3001070 PMID: 33481771

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