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ML 233

Cat. No. 5966 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Non-peptide apelin agonist
化学名： (E)-4-Methyl-5-(((phenylsulfonyl)oxy)imino)-[1,1'-bi(cyclohexane)]-3,6-dien-2-one
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ML 233

ML 233 is a non-peptide apelin receptor agonist (EC50 = 3.7 μM); exhibits >21-fold selectivity over the closely related angiotensin 1 receptor (EC50 = >79 μM).

技术数据 for ML 233

分子量 359.44
公式 C19H21NO4S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2080311-92-6
PubChem ID 60138111
InChI Key RSMZOLWJZGIWOV-CZIZESTLSA-N
Smiles CC(/C(C=C1C2CCCCC2)=N/OS(C3=CC=CC=C3)(=O)=O)=CC1=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ML 233

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 17.97 50

制备储备液 for ML 233

以下数据基于产品分子量 359.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 5.56 mL 27.82 mL 55.64 mL
2.5 mM 1.11 mL 5.56 mL 11.13 mL
5 mM 0.56 mL 2.78 mL 5.56 mL
25 mM 0.11 mL 0.56 mL 1.11 mL

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参考文献 for ML 233

参考文献是支持产品生物活性的出版物。

Yang et al (2015) Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system. Trends Pharmacol Sci. 36 560 PMID: 26143239

Khan et al (2011) Functional agonists of the apelin (APJ) receptor. Probe Reports from the NIH Molecular Libraries Program PMID: 22834038

If you know of a relevant reference for ML 233, please let us know.

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关键词: ML 233, ML 233 supplier, ML233, Potent, non, peptide, agonists, APJ, Receptors, Apelin, adipokines, 5966, Tocris Bioscience

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