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ML 335

Cat. No. 6887 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator
化学名： N-[(2,4-Dichlorophenyl)methyl]-4-[(methylsulfonyl)amino]benzamide
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ML 335

ML 335 is a selective K2P2.1 (TREK-1; KCNK2) and K2P10.1 (TREK-2; KCNK10) activator (EC50 values of 14.3 μM and 5.2 μM, respectively); directly stimulates the C-type gate via the K2P modulator pocket. Does not activate K2P4.1 (TRAAK).

技术数据 for ML 335

分子量 373.25
公式 C15H14Cl2N2O3S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 825658-06-8
PubChem ID 1243054
InChI Key RDFIQTZRJRVFHK-UHFFFAOYSA-N
Smiles CS(=O)(NC1=CC=C(C(NCC2=C(C=C(C=C2)Cl)Cl)=O)C=C1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ML 335

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 37.33 100
ethanol 7.46 20

制备储备液 for ML 335

以下数据基于产品分子量 373.25。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.68 mL 13.4 mL 26.79 mL
5 mM 0.54 mL 2.68 mL 5.36 mL
10 mM 0.27 mL 1.34 mL 2.68 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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参考文献 for ML 335

参考文献是支持产品生物活性的出版物。

Pope et al (2018) Protein and chemical determinants of BL-1249 action and selectivity for K2P channels. ACS Chem.Neurosci. 9 3153 PMID: 30089357

Gada et al (2019) Two-pore domain potassium channels: emerging targets for novel analgesic drugs: IUPHAR Review 26. Br.J.Pharmacol. 176 256 PMID: 30325008

Lolicato et al (2017) K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site. Nature 547 364 PMID: 28693035

Schewe et al (2019) A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels. Science 363 875 PMID: 30792303

If you know of a relevant reference for ML 335, please let us know.

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关键词: ML 335, ML 335 supplier, ML335, Selective, K2P2.1, TREK-1, KCNK2, K2P10.1, TREK-2, KCNK10, activators, activates, Two-P, Potassium, Channels, 6887, Tocris Bioscience

2 篇 ML 335 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ML 335 的部分引用包括：

Lei et al (2020) Recombinant CCL17 Enhances Hematoma Resolution and Activation of CCR4/ERK/Nrf2/CD163 Signaling Pathway After Intracerebral Hemorrhage in Mice. Neurotherapeutics 17 1940-1953 PMID: 32783091

Peng et al (2021) Albumin Reduces Oxidative Stress and Neuronal Apoptosis via the ERK/Nrf2/HO-1 Pathway after Intracerebral Hemorrhage in Rats. Oxid Med Cell Longev 2021 8891373 PMID: 33708336

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