ML 339

Cat. No. 5943 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective hCXCR6 antagonist

化学名： N-[(1R,3S,5S)-9-(2-((2-Chlorophenyl)amino)-2-exoethyl)-9-azabicyclo[3.3.1]nonan-3-yl)-3,4,5-trimethoxybenzamide

纯度： ≥98% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for ML 339

ML 339 is a potent and selective hCXCR6 antagonist (IC₅₀ = 140 nM); 100-fold less active at the murine CXCR6 receptor (IC₅₀ = 18 μM). Exhibits selectivity over CXCR5, CXCR4, CCR6 and APJ receptors (IC₅₀ >79 μM).

化合物库 for ML 339

ML 339 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for ML 339

分子量	502
公式	C₂₆H₃₂ClN₃O₅
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	2080300-49-6
PubChem ID	60202254
InChI Key	SSPYAPRDKNCABY-UHFFFAOYSA-N
Smiles	O=C(NC1=C(Cl)C=CC=C1)CN2[C@H]3CCC[C@@H]2C[C@](NC(C4=CC(OC)=C(OC)C(OC)=C4)=O)([H])C3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ML 339

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	50.2	100
	ethanol	10.04	20

制备储备液 for ML 339

以下数据基于产品分子量 502。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.99 mL	9.96 mL	19.92 mL
5 mM	0.4 mL	1.99 mL	3.98 mL
10 mM	0.2 mL	1 mL	1.99 mL
50 mM	0.04 mL	0.2 mL	0.4 mL

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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产品说明书 for ML 339

分析证书/产品说明书

化学品安全技术说明书

参考文献 for ML 339

参考文献是支持产品生物活性的出版物。

Hershberger et al (2012) Probing the CXCR6/CXCL16 Axis: targeting prevention of prostate cancer metastasis. Probe Reports from the NIH Molecular Libraries Program PMID: 24049849

If you know of a relevant reference for ML 339, please let us know.

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关键词: ML 339, ML 339 supplier, ML339, Potent, human, CXCR6, antagonists, antagonism, metastasis, Chemokine, CXC, Receptors, 5943, Tocris Bioscience

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