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Submit ReviewML 348
说明： Selective and reversible lysophospholipase 1 (LYPLA1) inhibitor
化学名： N-[2-Chloro-5-(trifluoromethyl)phenyl]-4-(2-furanylcarbonyl)-1-piperazineacetamide
纯度： ≥99% (HPLC)
生物活性 for ML 348
ML 348 is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM). Exhibits 14-fold selectivity for LYPLA1 over LYPLA2. Also selective over a panel of ~30 other serine hydrolases.
化合物库 for ML 348
ML 348 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for ML 348
| 分子量 | 415.79 |
| 公式 | C18H17ClF3N3O3 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 899713-86-1 |
| PubChem ID | 3238952 |
| InChI Key | OXKNHBBDOIMFFQ-UHFFFAOYSA-N |
| Smiles | ClC1=C(NC(CN2CCN(C(C3=CC=CO3)=O)CC2)=O)C=C(C(F)(F)F)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for ML 348
参考文献 for ML 348
参考文献是支持产品生物活性的出版物。
Adibekian et al (2013) Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 2 (LYPLA2). Probe Reports from the NIH Molecular Libraries Program PMID: 24624465
Hernandez et al (2017) APT2 inhibition restores Scribble localization and S-palmitoylation in Snail-transformed cells. Cell Chem.Bio. 24 87 PMID: 28065656
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关键词: ML 348, ML 348 supplier, ML348, selective, reversible, lysophospholipase, 1, lypla1, inhibitors, inhibits, APT1, acyl, protein, thioesterase, Other, Hydrolases, 5345, Tocris Bioscience
3 篇 ML 348 的引用文献
引用文献是使用了 Tocris 产品的出版物。 ML 348 的部分引用包括：
Zingler et al (2019) Palmitoylation is required for TNF-R1 signaling. Cell Commun Signal 17 90 PMID: 31382980
Francisco S et al (2021) Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains. Nat Chem Biol 17 438-447 PMID: 33707782
Vujic et al (2016) Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells. Oncotarget 7 7297 PMID: 26771141
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