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ML 349

Cat. No. 5344 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5344 has been discontinued.

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说明： Selective and reversible lysophospholipase 2 (LYPLA2) inhibitor
化学名： (5,5-Dioxido-4H-thieno[3,2-c][1]benzothiopyran-2-yl)[4-(4-methoxyphenyl)-1-piperazinyl]methanone
纯度： ≥98% (HPLC)
说明书
引用文献 (3)
评论
生物活性 技术数据 说明书 参考文献

生物活性 for ML 349

ML 349 is a selective and reversible lysophospholipase 2 (LYPLA2) inhibitor (IC50 = 144 nM). Displays selectively over LYPLA1 and 20 other serine hydrolases (IC50 values are >3000 and >10,000 nM respectively).

化合物库 for ML 349

ML 349 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for ML 349

分子量 454.56
公式 C23H22N2O4S2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 890819-86-0
PubChem ID 16193817
InChI Key YVIJPELUPZUEJX-UHFFFAOYSA-N
Smiles COC1=CC=C(N2CCN(C(C3=CC4=C(C(C=CC=C5)=C5S(C4)(=O)=O)S3)=O)CC2)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for ML 349

参考文献是支持产品生物活性的出版物。

Adibekian et al (2010) Characterization of a selective, reversible inhibitor of lysophospholipase 2 (LYPLA2). Probe Reports from the NIH Molecular Libraries Program PMID: 24624468

Hernandez et al (2017) APT2 inhibition restores Scribble localization and S-palmitoylation in Snail-transformed cells. Cell Che.Bio. 24 87 PMID: 28065656

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关键词: ML 349, ML 349 supplier, ML349, selective, reversible, Lysophospholipase, 2, LYPLA2, inhibitors, inhibits, serine, hydrolases, APT2, protein, acyl, thioesterase, Other, Hydrolases, 5344, Tocris Bioscience

3 篇 ML 349 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ML 349 的部分引用包括：

Zingler et al (2019) Palmitoylation is required for TNF-R1 signaling. Cell Commun Signal 17 90 PMID: 31382980

Francisco S et al (2021) Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains. Nat Chem Biol 17 438-447 PMID: 33707782

Vujic et al (2016) Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells. Oncotarget 7 7297 PMID: 26771141

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