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Submit ReviewML SA1
说明： Activator of TRPML channels
化学名： 2-[2-(3,4-Dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione
纯度： ≥98% (HPLC)
生物活性 for ML SA1
ML SA1 is an activator of TRPML channels (TRPML1, 2 and 3); does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels. Induces TRPML-mediated Ca2+ release from lysosomes; activity corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages. Activation of TRPML1 by ML SA1 causes membrane accumulation of aquaporin-3 and -5, and significant depolymerization of the actin cytoskeleton, in human lymphatic endothelial cells (HLECs).
化合物库 for ML SA1
ML SA1 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for ML SA1
| 分子量 | 362.42 |
| 公式 | C22H22N2O3 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 332382-54-4 |
| PubChem ID | 2880983 |
| InChI Key | KDDHBJICVBONAX-UHFFFAOYSA-N |
| Smiles | CC2CC(C)(C)N(C(CN3C(C(C=CC=C4)=C4C3=O)=O)=O)C1=CC=CC=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for ML SA1
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 7.25 | 20 |
制备储备液 for ML SA1
以下数据基于产品分子量 362.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 13.8 mL | 68.98 mL | 137.96 mL |
| 1 mM | 2.76 mL | 13.8 mL | 27.59 mL |
| 2 mM | 1.38 mL | 6.9 mL | 13.8 mL |
| 10 mM | 0.28 mL | 1.38 mL | 2.76 mL |
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产品说明书 for ML SA1
参考文献 for ML SA1
参考文献是支持产品生物活性的出版物。
Shen et al (2012) Lipid storage disorders block lysosomal trafficking by inhibiting TRP channel and calcium release. Nat.Commun. 3 731 PMID: 22415822
Weiss et al (2012) Cross-talk between TRPML1 channel, lipids and lysosomal storage diseases. Commun.Integr.Biol. 5 111 PMID: 22808310
Yang (2024) TRPML1 acts as a predisposing factor in lymphedema development by regulating the subcellular localization of aquaporin-3, -5. PLoS One 19 e0310653 PMID: 39637010
If you know of a relevant reference for ML SA1, please let us know.
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关键词: ML SA1, ML SA1 supplier, MLSA1, trpml, transient, receptor, potential, channels, mucolipin, TRPML1, TRPML2, TRPML3, lysosomal, lysosome, storage, diseases, TRPML, 4746, Tocris Bioscience
9 篇 ML SA1 的引用文献
引用文献是使用了 Tocris 产品的出版物。 ML SA1 的部分引用包括：
Yang et al (2024) TRPML1 acts as a predisposing factor in lymphedema development by regulating the subcellular localization of aquaporin-3, -5. PLoS One 19 e0310653 PMID: 39637010
Wei et al (2021) Berbamine inhibits Japanese encephalitis virus (JEV) infection by compromising TPRMLs-mediated endolysosomal trafficking of low-density lipoprotein receptor (LDLR). Emerg Microbes Infect 10 1257-1271 PMID: 34102949
Steven A et al (2022) Lysosomes and the pathogenesis of merosin-deficient congenital muscular dystrophy. Hum Mol Genet 31 733-747 PMID: 34568901
Haoxing et al (2022) A protocol to measure lysosomal Zn2+ release through a genetically encoded Zn2+ indicator. STAR Protoc 3 101453 PMID: 35707683
Yan et al (2022) LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function. EMBO J 41 e108119 PMID: 35099830
Jacques et al (2022) Microtubules restrict F-actin polymerization to the immune synapse via GEF-H1 to maintain polarity in lymphocytes. Elife 11 PMID: 36111670
Fine et al (2018) Structural basis for PtdInsP2-mediated human TRPML1 regulation. Nat.Commun. 9 4192 PMID: 30305615
Wim et al (2023) Phospholipase D3 degrades mitochondrial DNA to regulate nucleotide signaling and APP metabolism. Nat Commun 14 2847 PMID: 37225734
Ana-Maria et al (2020) Trpml controls actomyosin contractility and couples migration to phagocytosis in fly macrophages. J Cell Biol 219 PMID: 31940424
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Autophagy Scientific Review
Written by Patricia Boya and Patrice Codogno, this review summarizes the molecular mechanisms, physiology and pathology of autophagy. The role of autophagy in cell death and its links to disease are also discussed. Compounds available from Tocris are listed.
Autophagy Poster
Autophagy is a cellular process used by cells for degradation and recycling. Written by Patricia Boya and Patrice Codogno, this poster summarizes the molecular machinery, physiology and pathology of autophagy. Compounds available from Tocris are listed.