MM 07

Name: MM 07
Brand: Tocris Bioscience
SKU: 7053

Cat. No. 7053 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

7053 has been discontinued.

View all Apelin Receptors products.

说明： Apelin receptor biased agonist; exhibits bias for the G protein pathway

纯度： ≥95% (HPLC)

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for MM 07

MM 07 is an apelin biased agonist; exhibits bias for the G protein pathway. Stimulates endothelial NOS phosphorylation and expression, promotes proliferation, and attenuates apoptosis of human pulmonary arterial endothelial cells in vitro. Shows positive inotropic and vasodilatory effects in vivo and improves cardiac structure and function in a model of pulmonary arterial hypertension.

技术数据 for MM 07

分子量	1539.89
公式	C₆₇H₁₀₆N₂₂O₁₄S₃
序列	CRPRLCHKGPMPF (Modification: Disulfide bridge: 1-6)
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	1876450-21-3
PubChem ID	134828250
InChI Key	RKFGCZWTURNFPN-SVENNQHVSA-N
Smiles	O=C(N(CCC1)[C@@H]1C(N[C@H](C(O)=O)CC2=CC=CC=C2)=O)[C@H](CCSC)NC([C@H](CCC3)N3C(CNC([C@H](CCCCN)NC([C@@H](NC([C@H](CSSC[C@@H](C(N[C@@]4([H])CCCNC(N)=N)=O)N)NC([C@](NC([C@@H](NC([C@@](CCC5)([H])N5C4=O)=O)CCCNC(N)=N)=O)([H])CC(C)C)=O)=O)CC6=CN=CN6)=O)=O)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for MM 07

分析证书/产品说明书

化学品安全技术说明书

参考文献 for MM 07

参考文献是支持产品生物活性的出版物。

Brame et al (2015) Design, characterization, and first-in-human study of the vascular actions of a novel biased apelin receptor agonist. Hypertension 65 834 PMID: 25712721

Yang et al (2019) A novel cyclic biased agonist of the apelin receptor, MM07, is disease modifying in the rat monocrotaline model of pulmonary arterial hypertension. Br.J.Pharmacol. 176 1206 PMID: 30710493

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关键词: MM 07, MM 07 supplier, MM07, apelin, receptor, biased, agonists, agonism, G, protein, pathway, positive, inotropic, pulmonary, arterial, hypertension, PAH, Apelin, Receptors, 7053, Tocris Bioscience

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