Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewMMF
说明： Activator of Nrf2 pathway; primary metabolite of DMF (Cat. No. 4512)
别名： mono-Methyl fumarate
化学名： 2(E)-Butenedioic acid 1-methyl ester
纯度： ≥99% (HPLC)
生物活性 for MMF
MMF is a nuclear factor (erythroid-derived-2)-like 2 (Nrf2) pathway activator. Also exhibits agonist activity at GPR109A. Primary metabolite of DMF (Cat. No. 4512).
技术数据 for MMF
| 分子量 | 130.1 |
| 公式 | C5H6O4 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 2756-87-8 |
| PubChem ID | 5369209 |
| InChI Key | NKHAVTQWNUWKEO-NSCUHMNNSA-N |
| Smiles | O=C(/C=C/C(O)=O)OC |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for MMF
参考文献 for MMF
参考文献是支持产品生物活性的出版物。
Rao & Mishra (1998) Antihepatotoxic activity of monomethyl fumarate isolated from Fumaria indica. J.Ethnopharmacol. 60 207 PMID: 9613834
Scannevin et al (2012) Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway. J.Pharmacol.Exp.Ther. 341 274 PMID: 22267202
Hanson et al (2010) Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice. J.Clin.Invest. 120 2910 PMID: 20664170
Tang et al (2008) The psoriasis durg monomethylfumarate is a potent nicotinic receptor agonist. Biochem.Biophys.Res.Commun. 375 562 PMID: 18722346
Sciacovelli et al (2016) Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition Nature 537 544 PMID: 27580029
关键词: MMF, MMF supplier, monomethylfumarate, nuclear, factor, erythroid, derived, like, 2, pathway, Nrf2, activators, GPR109A, niacin, nicotinic, acid, receptors, agonists, metabolite, dimethylfumarate, DMF, mono-Methyl, fumarate, Antioxidants, Hydroxycarboxylic, Acid, Receptors, 4511, Tocris Bioscience
1 篇 MMF 的引用文献
引用文献是使用了 Tocris 产品的出版物。 MMF 的部分引用包括：
Cheng et al (2020) Furin inhibitors block SARS-CoV-2 spike protein cleavage to suppress virus production and cytopathic effects. Cell Rep.
MMF 的评论
目前没有该产品的评论。 Be the first to review MMF and earn rewards!
Have you used MMF?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image