Hydroxycarboxylic Acid Receptors
Hydroxycarboxylic acid (HCA) receptors are Gi/Go protein-coupled receptors for which hydroxycarboxylic acids are endogenous ligands. Three HCA receptors are known to exist: HCA1 (GPR81), HCA2 (GPR109A) and HCA3 (GPR109B).
Hydroxycarboxylic Acid Receptor Agonists |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 1762 | Acifran |
| Hypolipidemic agent; agonist for the GPR109A (HM74A) and GPR109B receptors | |
| 4599 | 3,5-DHBA |
| Selective HCA1 agonist | |
| 4622 | MK 1903 |
| Potent and selective GPR109A (HCA2) agonist | |
Hydroxycarboxylic acid (HCA) receptors, previously known as nicotinic acid receptors, are Gi/Go protein-coupled receptors for which hydroxycarboxylic acids are endogenous ligands. Three HCA receptors are known to exist: HCA1 (GPR81), HCA2 (GPR109A) and HCA3 (GPR109B).
GPR109B receptors originated from a gene duplication of GPR109A and have >95% homology. All subtypes are widely expressed throughout adipose tissue and are found at lower levels in macrophages, neutrophils, Langerhans cells and in the spleen. The human genes encoding these receptors are located on chromosome 12 (12q24.3).
External sources of pharmacological information for Hydroxycarboxylic Acid Receptors :
Hydroxycarboxylic Acid Receptor Gene Data
| Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|---|---|---|---|
| GPR81 | Human | GPR81 | NM_032554 | Q9BXC0 |
| Mouse | Gpr81 | NM_175520 | Q8C131 | |
| Rat | Gpr81 | XM_001079195 | XP_001072594 | |
| GPR109A | Human | NIACR1 | NM_177551 | Q8TDS4 |
| Mouse | Niacr1 | NM_030701 | Q9EP66 | |
| Rat | Niacr1 | NM_181476 | Q80Z39 | |
| GPR109B | Human | NIACR2 | NM_006018 | P49019 |