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MMG 11

Cat. No. 6858 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： TLR2 antagonist
化学名： Ethyl 5-(2-oxo-2-(2,3,4-trihydroxyphenyl)ethyl)furan-2-carboxylate
纯度： ≥97% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for MMG 11

MMG 11 is a TLR2 antagonist (IC50 values are in the range 1.7 - 5.7 μM). Exhibits selectivity for TLR2 over TLR4, TLR5, TLR7/8 and TLR9. Reduces TLR2-mediated cytokine secretion from PBMCs. MMG 11 preferentially inhibits TLR2/1- over TLR2/6-mediated NK-κB activation (IC50 values are 0.87 and 7.4 μM, respectively).

技术数据 for MMG 11

分子量 306.27
公式 C15H14O7
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 313254-94-3
PubChem ID 854609
InChI Key IIDUJWIVMGALOG-UHFFFAOYSA-N
Smiles CCOC(=O)C1=CC=C(CC(=O)C2=C(O)C(O)=C(O)C=C2)O1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for MMG 11

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 30.63 100
ethanol 15.31 50

制备储备液 for MMG 11

以下数据基于产品分子量 306.27。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.27 mL 16.33 mL 32.65 mL
5 mM 0.65 mL 3.27 mL 6.53 mL
10 mM 0.33 mL 1.63 mL 3.27 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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参考文献 for MMG 11

参考文献是支持产品生物活性的出版物。

Grabowski et al (2019) Identification of a pyrogallol derivative as a potent and selective human TLR2 antagonist by structure-based virtual screening. Biochem.Pharmacol. 154 148 PMID: 29684378

Grabowski et al (2020) The novel small-molecule antagonist MMG-11 preferentially inhibits TLR2/1 signaling. Biochem.Pharmacol. 171 113687 PMID: 31678495

If you know of a relevant reference for MMG 11, please let us know.

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关键词: MMG 11, MMG 11 supplier, MMG11, TLR2, antagonists, antagonism, toll-like, receptors, Toll-like, Receptors, 6858, Tocris Bioscience

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Pathways for MMG 11

Toll-like Receptor Signaling Pathway

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.