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Submit ReviewMMK 1
说明： Potent and selective FPR2 agonist
纯度： ≥95% (HPLC)
生物活性 for MMK 1
MMK 1 is a potent and selective human formyl peptide receptor FPR2 agonist (EC50 values are 1, 2 and > 10 000 nM at mFRP2, hFPR2 and hFPR1 respectively). Induces migration of human monocytes and neutrophils via a chemotactic mechanism and enhances production of proinflammatory cytokines IL-1β and IL-6. Also activates the neutrophil superoxide-generating NADPH-oxidase.
DMSO is not recommended as a solvent for this peptide.
技术数据 for MMK 1
| 分子量 | 1610.97 |
| 公式 | C75H123N19O18S |
| 序列 | LESIFRSLLFRVM |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 271246-66-3 |
| PubChem ID | 25074458 |
| InChI Key | PWBQRCXCXXGUGY-AJOXZCOLSA-N |
| Smiles | [H]N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCSC)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for MMK 1
参考文献 for MMK 1
参考文献是支持产品生物活性的出版物。
Hu et al (2001) Synthetic peptide MMK-1 is a highly specific chemotactic agonist for leukocyte FPRL1. J.Leukoc.Biol. 70 155 PMID: 11435499
Klein et al (1998) Identification of surrogate agonists for the human FPRL-1 receptor by autocrine selection in yeast. Nature Biotech. 16 1334
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关键词: MMK 1, MMK 1 supplier, Potent, selective, FPR2, agonists, FPRL, Formyl, Peptide, Receptors, MMK1, 3537, Tocris Bioscience
2 篇 MMK 1 的引用文献
引用文献是使用了 Tocris 产品的出版物。 MMK 1 的部分引用包括：
Akoume et al (2019) A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression. Sci Rep 9 10074 PMID: 31296888
Leoni et al (2013) Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. J Clin Invest 123 443 PMID: 23241962
MMK 1 的评论
平均评分: 4 (Based on 1 Review.)
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Following protocol.
By
Christopher Durrant on 01/09/2020
分析类型： Ex Vivo
种属： Human
looking at human formyl peptide receptor
Followed publication