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说明： Potent and selective tankyrase inhibitor
化学名： 2-[4-(1-Methylethyl)phenyl]-4H-1-benzopyran-4-one
纯度： ≥98% (HPLC)
生物活性 for MN 64
Potent and selective tankyrase (TNKS) inhibitor (IC50 values are 6 and 72 nM for TNKS1 and TNKS2 respectively). Has no significant effect on PARP-1 or PARP-2 (IC50 >19 μM). Inhibits WNT/β-catenin signaling-dependent Super-TopFlash (STF) luciferase activity.
技术数据 for MN 64
| 分子量 | 264.32 |
| 公式 | C18H16O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 92831-11-3 |
| PubChem ID | 2802462 |
| InChI Key | PYTOHIUBXSJKQH-UHFFFAOYSA-N |
| Smiles | O=C2C1=CC=CC=C1OC(C3=CC=C(C(C)C)C=C3)=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for MN 64
参考文献 for MN 64
参考文献是支持产品生物活性的出版物。
Narwal et al (2013) Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J.Med.Chem. 56 7880 PMID: 24116873
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关键词: MN 64, MN 64 supplier, MN64, potent, selective, tankyrase, inhibitors, TNKS, TNKS1, TNKS2, WNT, inhibits, Poly(ADP-ribose), Polymerase, Tankyrase, 5084, Tocris Bioscience
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