MPC 6827 hydrochloride

Name: MPC 6827 hydrochloride
Brand: Tocris Bioscience
SKU: 5231

Cat. No. 5231 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5231 has been discontinued.

View all Microtubules products.

说明： Inhibitor of microtubule polymerization; antimitotic and antitumor

化学名： N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine hydrochloride

纯度： ≥98% (HPLC)

说明书

引用文献 (2)

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for MPC 6827 hydrochloride

MPC 6827 hydrochloride is a potent inhibitor of microtubule formation (IC₅₀ = 1.5 - 3.4 nM); inhibits polymerization of tubulin in vitro and disrupts microtubule formation in several cancer cell lines. Inhibits tumor growth in vitro and in vivo; exhibits pro-apoptotic characteristics. Brain penetrant.

技术数据 for MPC 6827 hydrochloride

分子量	315.8
公式	C₁₇H₁₇N₃O.HCl
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	917369-31-4
PubChem ID	11638255
InChI Key	VYUWDIKZJLOZJL-UHFFFAOYSA-N
Smiles	CC2=NC1=CC=CC=C1C(N(C)C3=CC=C(OC)C=C3)=N2.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for MPC 6827 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for MPC 6827 hydrochloride

参考文献是支持产品生物活性的出版物。

Mahal et al (2014) Effects of the tumor-vasculature-disrupting agent verubulin and two heteroaryl analogues on cancer cells, endothelial cells, and blood vessels. ChemMedChem. 9 847 PMID: 24678059

Kasibhatla et al (2007) MPC-6827: a small-molecule inhibitor of microtubule formation that is not a substrate for multidrug resistance pumps. Cancer Res. 67 5865 PMID: 17575155

Sirisoma et al (2009) Discovery of N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine, a potent apoptosis inducer and efficacious anticancer agent with high blood brain barrier penetration. J.Med.Chem. 52 2341 PMID: 19296653

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2 篇 MPC 6827 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 MPC 6827 hydrochloride 的部分引用包括：

Christopher T et al (2022) Initial Evaluations of the Microtubule-Based PET Radiotracer, [11C]MPC-6827 in a Rodent Model of Cocaine Abuse. Front Med (Lausanne) 9 817274 PMID: 35295607

Suzanne et al (2022) Preliminary mechanistic insights of a brain-penetrant microtubule imaging PET ligand in a tau-knockout mouse model. EJNMMI Res 12 41 PMID: 35881263