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说明： SARS-CoV-2 M^pro Degrader (PROTAC^®)

化学名： 3-((6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)hexyl)oxy)benzyl ((2S,3R)-3-(tert-butoxy)-1-(((S)-3-cyclohexyl-1-oxo-1-(((S)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)amino)propan-2-yl)amino)-1-oxobutan-2-yl)carbamate

说明书

引用文献

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for MPD 2

MPD 2 is a SARS-CoV-2 M^pro Degrader (PROTAC^®) (DC₅₀ = 296 nM in 293T cells). M^pro degradation is time-dependent and CRBN-mediated. Antiviral in A549-ACE2 cells infected with several SARS-CoV-2 strains (EC₅₀ = 492 nM at delta variant) and against a nirmatrelvir-resistant mutant of SARS-CoV-2, NSP5 E166A (EC₅₀ = 460 nM).

技术数据 for MPD 2

分子量	973.13
公式	C₅₁H₆₈N₆O₁₃
储存	Store at -20°C
PubChem ID	171663340
InChI Key	ZKSDAFLRLHGTNH-DTKLLKMQSA-N
Smiles	O=C1[C@@H](CCN1)C[C@H](NC([C@@H](NC([C@@H](NC(OCC2=CC(OCCCCCCOC3=C4C(C(N(C4=O)C5CCC(NC5=O)=O)=O)=CC=C3)=CC=C2)=O)[C@@H](C)OC(C)(C)C)=O)CC6CCCCC6)=O)C([H])=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for MPD 2

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	97.31	100

制备储备液 for MPD 2

以下数据基于产品分子量 973.13。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.03 mL	5.14 mL	10.28 mL
5 mM	0.21 mL	1.03 mL	2.06 mL
10 mM	0.1 mL	0.51 mL	1.03 mL
50 mM	0.02 mL	0.1 mL	0.21 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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产品说明书 for MPD 2

分析证书/产品说明书

化学品安全技术说明书

参考文献 for MPD 2

参考文献是支持产品生物活性的出版物。

Alugubelli et al (2024) Discovery of first-in-class PROTAC Degraders of SARS-CoV-2 main protease. J.Med.Chem. 67 6495 PMID: 38608245

If you know of a relevant reference for MPD 2, please let us know.

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关键词: MPD 2, MPD 2 supplier, MPD2, degrader, degraders, degrade, degrades, Mpro, main, protease, SARS-CoV-2, sars, cov, protac, proteolysis, targeting, chimera, CRBN, cereblon, e3, ligase, Other, Degraders, 3C, and, 3CL, Proteases, 8802, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

TPD and Induced Proximity Research Product GuideUpdated

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

Active Degraders
TAG Degradation Platform
Degrader Building Blocks
Assays for Protein Degradation
Induced Proximity Tools

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia

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