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MRE 3008F20

Cat. No. 4041 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4041 has been discontinued.

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说明： Highly potent and selective adenosine A3 receptor antagonist
化学名： N-[2-(2-Furanyl)-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl]-N'-(4-methoxyphenyl)urea
纯度： ≥98% (HPLC)
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引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for MRE 3008F20

MRE 3008F20 is a potent adenosine A3 receptor competitive antagonist. Selective for human A3 receptors over human A1 and A2A receptors (Ki values are 0.29, 141 and 1197 nM respectively). Potently inhibits agonist-induced cyclic AMP elevation in resting T lymphocytes (IC50 = 5 nM).

技术数据 for MRE 3008F20

分子量 432.44
公式 C21H20N8O3
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 252979-43-4
PubChem ID 5310960
InChI Key CJRNHKSLHHWUAB-UHFFFAOYSA-N
Smiles O=C(NC4=CC=C(OC)C=C4)NC2=NC1=NN(CCC)C=C1C3=NC(C5=CC=CO5)=NN23

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for MRE 3008F20

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参考文献 for MRE 3008F20

参考文献是支持产品生物活性的出版物。

Gessi et al (2004) Expression of A3 adenosine receptors in human lymphocytes: up-regulation in T cell activation. Mol.Pharmacol. 65 711 PMID: 14978250

Varani et al (2010) Expression and functional role of adenosine receptors in regulating inflammatory responses in human synoviocytes. Br.J.Pharmacol. 160 101 PMID: 20331607

Baraldi et al (1999) Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists. J.Med.Chem. 42 4473 PMID: 10579811

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关键词: MRE 3008F20, MRE 3008F20 supplier, adenosine, A3, receptors, potent, selective, competitive, antagonists, A3AR, MRE3008F20, hA3, Adenosine, Receptors, 4041, Tocris Bioscience

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