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MRK 740

Cat. No. 6803 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6803 has been discontinued.

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说明： Potent PRDM9 inhibitor
化学名： 3-(3,5-Dimethoxyphenyl)-5-(1-methyl-9-(2-methylpyridin-4-yl)-1,4,9-triazaspiro[5.5]undecan-4-yl)-1,2,4-oxadiazole
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 说明书 参考文献

生物活性 for MRK 740

MRK 740 is a potent PRDM9 histone methyltransferase inhibitor (IC50 = 85 nM for in vitro methylation of H3K4), which displays >100-fold selectivity over other histone methyltransferases. MRK 740 inhibits H3K4 methylation in cells (IC50 = 0.8 μM).

许可信息

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MRK-740 probe summary on the SGC website.

External Portal Information for MRK 740

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of MRK 740 is reviewed on the chemical probes website.

化合物库 for MRK 740

MRK 740 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for MRK 740

分子量 464.56
公式 C25H32N6O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2387510-80-5
PubChem ID 137331596
InChI Key NZYTZRHHBAJPKN-UHFFFAOYSA-N
Smiles CC1=CC(N2CCC3(CC2)CN(CCN3C)C4=NC(C5=CC(OC)=CC(OC)=C5)=NO4)=CC=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for MRK 740

参考文献是支持产品生物活性的出版物。

Allali-Hassani et al (2019) Discovery of a chemical probe for PRDM9. Nat.Commun. 10 5759 PMID: 31848333

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关键词: MRK 740, MRK 740 supplier, MRK740, histone, lysine, methyltransferase, inhibitors, inhibits, potent, PRDM9, PR, domain, zinc, finger, protein, 9, Other, Lysine, Methyltransferases, 6803, Tocris Bioscience

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