MRS 1334

Discontinued Product

1385 has been discontinued.

View all Adenosine A<sub>3</sub> Receptors products.
说明: Potent, highly selective hA3 antagonist
化学名: 1,4-Dihydro-2-methyl-6-phenyl-4-(phenylethynyl)-3,5-pyridinedicarboxylic acid 3-ethyl-5-[(3-nitrophenyl)methyl] ester
纯度: ≥98% (HPLC)
说明书
引用文献 (6)
评论

生物活性 for MRS 1334

MRS 1334 is a potent and highly selective antagonist for the human adenosine A3 receptor. Ki values are 2.69 nM at hA3, and > 100 μM at rat A1 and rat A2A receptors.

许可信息

Sold with the permission of the NIH, US Patent 60/029,855

技术数据 for MRS 1334

分子量 522.56
公式 C31H26N2O6
储存 Desiccate at -20°C
纯度 ≥98% (HPLC)
CAS Number 192053-05-7
PubChem ID 4519822
InChI Key QFLOJAMZLQXHFS-UHFFFAOYSA-N
Smiles CCOC(=O)C1=C(C)NC(C2=CC=CC=C2)=C(C1C#CC1=CC=CC=C1)C(=O)OCC1=CC=C(C=C1)N(=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for MRS 1334

分析证书/产品说明书
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参考文献 for MRS 1334

参考文献是支持产品生物活性的出版物。

Baraldi and Borea (2000) New potent and selective human adenosine A3 receptor antagonists. TiPS 21 456 PMID: 11121831

Li et al (1998) Structure-activity relationships and molecular modeling of 3,5-diacyl-2,4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists. J.Med.Chem. 41 3186 PMID: 9703464

Corriden et al (2013) Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes. EMBO.Rep. 14 726 PMID: 23817552

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关键词: MRS 1334, MRS 1334 supplier, Potent, selective, hA3, antagonists, Receptors, adenosines, MRS1334, Adenosine, A3, 1385, Tocris Bioscience

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