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Submit ReviewMRS 2693 trisodium salt
说明： Selective P2Y6 agonist
别名： 5-Iodo-UDP trisodium salt
化学名： 5-Iodouridine-5'-O-diphosphate trisodium salt
纯度： ≥95% (HPLC)
生物活性 for MRS 2693 trisodium salt
MRS 2693 trisodium salt is a selective P2Y6 agonist (EC50 = 0.015 μM at the hP2Y6 receptor). Displays no activity at other P2Y subtypes. Exerts a cytoprotective effect in an in vivo mouse model of hindlimb skeletal muscle ischemia/reperfusion injury.
技术数据 for MRS 2693 trisodium salt
| 分子量 | 596 |
| 公式 | C9H10IN2Na3O12P2 |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 1448858-83-0 |
| PubChem ID | 90488768 |
| InChI Key | QWGVSYFNEAILDQ-FCIXCQMASA-K |
| Smiles | [Na+].[Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP([O-])([O-])=O)N1C=C(I)C(=O)NC1=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for MRS 2693 trisodium salt
| 溶解性 | Soluble in water (supplied pre-dissolved at a concentration of 10mM) |
产品说明书 for MRS 2693 trisodium salt
参考文献 for MRS 2693 trisodium salt
参考文献是支持产品生物活性的出版物。
Besada et al (2006) Structure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y6 receptor. J.Med.Chem. 49 5532 PMID: 16942026
Mamedova et al (2008) Attenuation of apoptosis in vitro and ischemia/reperfusion injury in vivo in mouse skeletal muscle by P2Y6 receptor activation. Pharmacol.Res. 58 232 PMID: 18805489
Jacobson et al (2009) Development of selective agonists and antagonists of P2Y receptors. Purinerg.Sig. 5 75
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关键词: MRS 2693 trisodium salt, MRS 2693 trisodium salt supplier, Selective, P2Y6, purinergic, receptors, agonists, MRS2693, trisodium, salt, 5-Iodo-UDP, Purinergic, P2Y, Receptors, 2502, Tocris Bioscience
4 篇 MRS 2693 trisodium salt 的引用文献
引用文献是使用了 Tocris 产品的出版物。 MRS 2693 trisodium salt 的部分引用包括：
Moreira-Souza et al (2015) Pyrimidinergic Receptor Activation Controls Toxoplasma gondii Infection in Macrophages. PLoS One 10 e0133502 PMID: 26192447
Matsumoto et al (2011) Uridine adenosine tetraphosphate-induced contraction is increased in renal but not pulmonary arteries from DOCA-salt hypertensive rats. Am J Physiol Heart Circ Physiol 301 H409 PMID: 21551273
Yu et al (2013) Extracellular UDP enhances P2X-mediated bladder smooth muscle contractility via P2Y(6) activation of the phospholipase C/inositol trisphosphate pathway. FASEB J 27 1895 PMID: 23362118
Obba et al (2015) The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML. Neuropharmacology 11 1114 PMID: 26029847
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MRS 2693 trisodium salt 的评论
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Good product.
By
Anonymous on 09/09/2021
分析类型： In Vitro
种属： Human
细胞系/组织： 1321N1
Used MRS 2693 in a fluorescence-based intracellular calcium assay, and the agonist came pre-dissolved in water to a concentration of 10 mM.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.