MRS 2768 tetrasodium salt

Cat. No. 3884 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective P2Y₂ agonist

化学名： Uridine-5'-tetraphosphate δ-phenyl ester tetrasodium salt

纯度： ≥98% (HPLC)

引用文献 (5)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for MRS 2768 tetrasodium salt

MRS 2768 tetrasodium salt is a selective P2Y₂ agonist (EC₅₀ = 1.89 μM). Displays no affinity for human P2Y₄ or P2Y₆ receptors. In a mouse model of myocardial infarction, pre-treatment with MRS 2768 protects cardiocytes and heart tissue from ischemic damage, and reduces circulating levels of TNF-α.

技术数据 for MRS 2768 tetrasodium salt

分子量	728.14
公式	C₁₅H₁₆N₂O₁₈P₄Na₄
储存	Store at -80°C
纯度	≥98% (HPLC)
CAS Number	2567869-47-8
PubChem ID	90488893
InChI Key	ASYFBNZFGLWLNC-YYXHNCPRSA-J
Smiles	[Na+].[Na+].[Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP([O-])(=O)OP([O-])(=O)OP([O-])(=O)OC1=CC=CC=C1)N1C=CC(=O)NC1=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for MRS 2768 tetrasodium salt

溶解性	Soluble in water (supplied pre-dissolved at a concentration of 10mM)

产品说明书 for MRS 2768 tetrasodium salt

分析证书/产品说明书

化学品安全技术说明书

参考文献 for MRS 2768 tetrasodium salt

参考文献是支持产品生物活性的出版物。

Ko et al (2008) Synthesis and potency of novel uracil nucleotides and derivatives as P2Y₂ and P2Y₆ receptor agonists. Bioorg.Med.Chem. 16 6319 PMID: 18514530

Hochhauser et al (2013) P2Y2 receptor agonist with enhanced stability protects the heart from ischemic damage in vitro and in vivo. Purinergic Signal. 9 633 PMID: 23828651

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关键词: MRS 2768 tetrasodium salt, MRS 2768 tetrasodium salt supplier, selective, P2Y2, agonists, purinergic, receptors, MRS2768, 1047980-83-5, Purinergic, P2Y, Receptors, 3884, Tocris Bioscience

5 篇 MRS 2768 tetrasodium salt 的引用文献

引用文献是使用了 Tocris 产品的出版物。 MRS 2768 tetrasodium salt 的部分引用包括：

Ilatovskaya et al (2013) Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli. Am J Physiol Cell Physiol 305 C1050 PMID: 24048730

Trabanelli et al (2012) Extracellular ATP exerts opposite effects on activated and regulatory CD4+ T cells via purinergic P2 receptor activation. J Immunol 189 1303 PMID: 22753942

Andreas et al (2020) Osmotic and hypoxic induction of osteopontin in retinal pigment epithelial cells: Involvement of purinergic receptor signaling. Mol Vis 26 188-203 PMID: 32214785

Shabir et al (2013) Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium. PLoS Comput Biol 305 F396 PMID: 23720349

Alsaqati et al (2013) Investigation of the functional expression of purine and pyrimidine receptors in porcine isolated pancreatic arteries. Purinergic Signal 10 241 PMID: 24310605

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