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Submit ReviewMRS 5698
Discontinued Product
5428 has been discontinued.
View all Adenosine A<sub>3</sub> Receptors products.
说明： High affinity and selective A3 agonist
化学名： (1S,2R,3S,4R,5S)-4-[6-[[(3-Chlorophenyl)methyl]amino]-2-[2-(3,4-difluorophenyl)ethynyl]-9H-purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
纯度： ≥95% (HPLC)
生物活性 for MRS 5698
MRS 5698 is a high affinity and selective A3 adenosine receptor agonist (Ki ~ 3 nM); displays >1000-fold selectivity over A1 and A2A adenosine receptors. Reverses mechanoallodynia in several neuropathic pain models in vivo. Orally bioavailable.
技术数据 for MRS 5698
| 分子量 | 564.97 |
| 公式 | C28H23ClF2N6O3 |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 1377273-00-1 |
| PubChem ID | 57523213 |
| InChI Key | LYLLLJJYBWLGHW-CIZVZKTGSA-N |
| Smiles | O=[C@](NC)[C@@]1(C2)[C@H]2[C@@H](N3C(N=C(C#CC6=CC(F)=C(F)C=C6)N=C4NCC5=CC(Cl)=CC=C5)=C4N=C3)[C@H](O)[C@@H]1O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for MRS 5698
参考文献 for MRS 5698
参考文献是支持产品生物活性的出版物。
Little et al (2015) Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states. Brain 138 28 PMID: 25414036
Tosh et al (2012) Structure-guided design of A3 adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions. J.Med.Chem. 55 4847 PMID: 22559880
Tosh et al (2015) Efficient, large-scale synthesis and preclinical studies of MRS5698, a highly selective A3 adenosine receptor agonist that protects against chronic neuropathic pain. Purinergic Signal. 11 371 PMID: 26111639
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关键词: MRS 5698, MRS 5698 supplier, High, affinity, selective, A3, adenosine, receptors, agonists, antinociceptive, MRS5698, Adenosine, Receptors, 5428, Tocris Bioscience
2 篇 MRS 5698 的引用文献
引用文献是使用了 Tocris 产品的出版物。 MRS 5698 的部分引用包括：
Lei et al (2018) Genetic ablation of adenosine receptor A3 results in articular cartilage degeneration. J Mol Med (Berl) 96 1049-1060 PMID: 30088034
Fong et al (2019) Antitumor effects of MRS5698, a cordycepin derivative, on endometrial cancer cells Natural Product Communications 14 1
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