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MRT 10

Cat. No. 4585 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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4585 has been discontinued.

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说明： Smoothened (Smo) antagonist
化学名： N-[[[3-Benzoylamino)phenyl]amino]thioxomethyl]-3,4,5-trimethoxybenzamide
纯度： ≥98%
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引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for MRT 10

MRT 10 is a smoothened (Smo) receptor antagonist (IC50 = 0.5 μM in HEK293 cells transiently expressing mouse Smo). Inhibits ShhN-induced Gli luciferase reporter activity in Shh-light 2 cells (IC50 = 2.5 μM); acts as an inverse agonist during nontranscriptional Hedgehog pathway activation (IC50 = 2.5 μM in HEK293 cells).

技术数据 for MRT 10

分子量 465.52
公式 C24H23N3O5S
储存 Store at +4°C
纯度 ≥98%
CAS Number 330829-30-6
PubChem ID 1139102
InChI Key KVQVEZQDNHMQJV-UHFFFAOYSA-N
Smiles O=C(NC(NC2=CC(NC(C3=CC=CC=C3)=O)=CC=C2)=S)C1=CC(OC)=C(OC)C(OC)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for MRT 10

参考文献是支持产品生物活性的出版物。

Solinas et al (2012) Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity. J.Med.Chem. 55 1559 PMID: 22268551

Manetti et al (2010) Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as smoothened antagonists. Mol.Pharmacol. 78 658 PMID: 20664000

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关键词: MRT 10, MRT 10 supplier, MRT10, smoothened, receptor, antagonists, inhibitors, inhibits, hedgehog, pathway, inverse, agonists, nontranscriptional, Gli, Shh, sonic, Smoothened, Receptors, Hedgehog, Signaling, 4585, Tocris Bioscience

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