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MS 023 dihydrochloride

Cat. No. 5713 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective type I PRMT inhibitor
化学名： N1-Methyl-N1-[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]-1,2-ethanediamine dihydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献 (3)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for MS 023 dihydrochloride

MS 023 dihydrochloride is a potent and selective type I PRMT inhibitor (IC50 values are 8, 8, 30, 83 and 119 nM for PRMT6, PRMT8, PRMT1, PRMT4 and PRMT3, respectively). Exhibits no significant activity against type II and III PRMTs, PKMTs, DNMTs, KDMs and reader proteins. Reduces global arginine asymmetric dimethylation levels in vitro. Also inhibits and reduces TGF-β-activated kinase 1 expression and protein levels.

许可信息

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MS023 probe summary on the SGC website.

External Portal Information for MS 023 dihydrochloride

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of MS023 is reviewed on the chemical probes website.

技术数据 for MS 023 dihydrochloride

分子量 360.32
公式 C17H25N3O.2HCl
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1992047-64-9
PubChem ID 121513886
InChI Key HCNXCUFNZWGILO-UHFFFAOYSA-N
Smiles CC(C)OC1=CC=C(C2=CNC=C2CN(CCN)C)C=C1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for MS 023 dihydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 36.03 100
DMSO 36.03 100

制备储备液 for MS 023 dihydrochloride

以下数据基于产品分子量 360.32。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.78 mL 13.88 mL 27.75 mL
5 mM 0.56 mL 2.78 mL 5.55 mL
10 mM 0.28 mL 1.39 mL 2.78 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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产品说明书 for MS 023 dihydrochloride

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for MS 023 dihydrochloride

参考文献是支持产品生物活性的出版物。

Eram et al (2016) A potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases. ACS Chem.Biol. 11 772 PMID: 26598975

Scheer et al (2019) A chemical biology toolbox to study protein methyltransferases and epigenetic signaling. Nat.Commun. 11 19 PMID: 30604761

If you know of a relevant reference for MS 023 dihydrochloride, please let us know.

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关键词: MS 023 dihydrochloride, MS 023 dihydrochloride supplier, MS023, dihydrochloride, potent, Type-1, selective, PRMT, inhibitors, inhibits, PRMT6, PRMT8, PRMT1, PRMT4, PRMT3, Protein, Arginine, Methyltransferases, 5713, Tocris Bioscience

3 篇 MS 023 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 MS 023 dihydrochloride 的部分引用包括：

Tang et al (2022) A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancer. Cell Rep. 38 110417 PMID: 35196489

Lu et al (2021) Pharmacologic modulation of RNA splicing enhances anti-tumor immunity. Cell PMID: 34171309

Choucair et al (2019) The arginine methyltransferase PRMT1 regulates IGF-1 signaling in breast cancer. Oncogene 38 4015 PMID: 30692633

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Epigenetics Scientific Review

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Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.